Delphinidin, one of the major anthocyanidins, prevents bone loss through the inhibition of excessive osteoclastogenesis in osteoporosis model mice

Anthocyanins, one of the flavonoid subtypes, are a large family of water-soluble phytopigments and have a wide range of health-promoting benefits. Recently, an anthocyanin-rich compound from blueberries was reported to possess protective property against bone loss in ovariectomized (OVX) animal mode...

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Veröffentlicht in:	PloS one 2014-05, Vol.9 (5), p.e97177-e97177
Hauptverfasser:	Moriwaki, Sawako, Suzuki, Keiko, Muramatsu, Masashi, Nomura, Atsushi, Inoue, Fumihide, Into, Takeshi, Yoshiko, Yuji, Niida, Shumpei
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animal models Animals Anthocyanins Anthocyanins - administration & dosage Anthocyanins - analysis Anthocyanins - pharmacology Anthocyanins - therapeutic use Berries Bioavailability Biocompatibility Biology and Life Sciences Biomedical materials Blueberries Blueberry Plants - chemistry Bone density Bone loss Bone resorption Bone Resorption - prevention & control c-Fos protein Cancer Cell cycle Cell Line Dentistry Differentiation Female Flavonoids Fos protein Fruits Gene expression Genomics Geriatrics Gerontology Health promotion Laboratories Medicine and Health Sciences Metabolism Mice Mice, Inbred C57BL NF-kappa B - metabolism NF-κB protein NFATC Transcription Factors - metabolism Older people Oral administration Osteoclastogenesis Osteoclasts Osteoclasts - drug effects Osteoporosis Osteoporosis - prevention & control Ovariectomy Physical Sciences Polyphenols Post-menopause Proteomics Proto-Oncogene Proteins c-fos - metabolism Real-Time Polymerase Chain Reaction Research and Analysis Methods Reverse Transcriptase Polymerase Chain Reaction Rodents TRANCE protein Transcription factors Vegetables X-Ray Microtomography
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