FOXM1 modulates cisplatin sensitivity by regulating EXO1 in ovarian cancer

Cisplatin is commonly used in ovarian cancer chemotherapy, however, chemoresistance to cisplatin remains a great clinical challenge. Oncogenic transcriptional factor FOXM1 has been reported to be overexpressed in ovarian cancer. In this study, we aimed to investigate the potential role of FOXM1 in o...

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Veröffentlicht in:	PloS one 2014-05, Vol.9 (5), p.e96989
Hauptverfasser:	Zhou, Jinhua, Wang, Yunfei, Wang, You, Yin, Xia, He, Yifeng, Chen, Lilan, Wang, Wenwen, Liu, Ting, Di, Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Biology and life sciences Breast cancer Cancer Cancer therapies Cell cycle Cell growth Cell Line, Tumor Chemoresistance Chemotherapy Cisplatin Cisplatin - pharmacology Cisplatin - therapeutic use Cytotoxicity Deoxyribonucleic acid DNA DNA damage DNA repair DNA Repair - drug effects DNA Repair Enzymes - metabolism Drug Resistance, Neoplasm Education Exodeoxyribonucleases - metabolism Female Forkhead Box Protein M1 Forkhead Transcription Factors - metabolism Gene expression Gynecology Hospitals Humans Kinases Laboratories Medicine Medicine and Health Sciences Obstetrics Oncology Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - drug therapy Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Ovary - drug effects Ovary - metabolism Ovary - pathology Ribonucleic acid RNA Sensitivity siRNA Toxicity Transcription factors Up-Regulation
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