Administration of BMSCs with muscone in rats with gentamicin-induced AKI improves their therapeutic efficacy

The therapeutic action of bone marrow-derived mesenchymal stem cells (BMSCs) in acute kidney injury (AKI) has been reported by several groups. However, recent studies indicated that BMSCs homed to kidney tissues at very low levels after transplantation. The lack of specific homing of exogenously inf...

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Veröffentlicht in:	PloS one 2014-05, Vol.9 (5), p.e97123
Hauptverfasser:	Liu, Pengfei, Feng, Yetong, Dong, Chao, Yang, Dandan, Li, Bo, Chen, Xin, Zhang, Zhongjun, Wang, Yi, Zhou, Yulai, Zhao, Lei
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - chemically induced Acute Kidney Injury - therapy Administration, Intravenous Analysis of Variance Animal tissues Animals Apoptosis Apoptosis - physiology Biological activity Biology and Life Sciences Blotting, Western Bone marrow Bone marrow transplantation Cell Movement - drug effects Cell Proliferation - drug effects Chemokine CCL5 CXCR4 protein Cycloparaffins - administration & dosage Cycloparaffins - pharmacology DNA Primers - genetics Drug Delivery Systems - methods Flow Cytometry Gentamicin Gentamicins - adverse effects Homing Immunohistochemistry In Situ Nick-End Labeling Medicine and Health Sciences Mesenchymal Stem Cell Transplantation - methods Mesenchyme Mortality Rats Real-Time Polymerase Chain Reaction Receptors, CXCR - metabolism Receptors, CXCR4 - metabolism Rodents Stem cells Studies Transplantation Urine
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