Lipid profiling and transcriptomic analysis reveals a functional interplay between estradiol and growth hormone in liver

17β-estradiol (E2) may interfere with endocrine, metabolic, and gender-differentiated functions in liver in both females and males. Indirect mechanisms play a crucial role because of the E2 influence on the pituitary GH secretion and the GHR-JAK2-STAT5 signaling pathway in the target tissues. E2, th...

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Veröffentlicht in:	PloS one 2014-05, Vol.9 (5), p.e96305
Hauptverfasser:	Fernández-Pérez, Leandro, Santana-Farré, Ruymán, de Mirecki-Garrido, Mercedes, García, Irma, Guerra, Borja, Mateo-Díaz, Carlos, Iglesias-Gato, Diego, Díaz-Chico, Juan Carlos, Flores-Morales, Amilcar, Díaz, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Amino acids Animals Biology and Life Sciences Biophysics Cancer Cholesterol Endocrinology Esters Estradiol Estradiol - pharmacology Estrogen Estrogens Estrogens - pharmacology Fatty acids Fatty Acids - analysis Fatty liver Females Gene expression Gene Expression Profiling Gene Expression Regulation - drug effects Gene Regulatory Networks - drug effects Genes Genomics Genotype & phenotype Growth hormone Growth Hormone - pharmacology Growth hormones Homeostasis Hormones Hypothyroidism Hypothyroidism - genetics Immune response Influence Inhibition Janus kinase 2 Kinases Laboratories Lipid metabolism Lipid Metabolism - genetics Lipids Lipids - analysis Lipids - blood Liver Liver - drug effects Liver - metabolism Male Males Medical research Medicine and Health Sciences Metabolic syndrome Metabolism Models, Genetic Molecular modelling Oligonucleotide Array Sequence Analysis Orchiectomy Oxidation Phenols (Class of compounds) Physiology Pituitary Proteins Rats, Sprague-Dawley Research and Analysis Methods Reverse Transcriptase Polymerase Chain Reaction Rodents Saturated fatty acids Sex hormones Signal transduction Signal Transduction - drug effects Signal Transduction - genetics Signaling Somatotropin Stat5 protein Studies Thyroid hormones Tissues Transcription Transcriptome - genetics Triglycerides Urea Xenobiotics
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