Massively parallel sequencing of human urinary exosome/microvesicle RNA reveals a predominance of non-coding RNA

Intact RNA from exosomes/microvesicles (collectively referred to as microvesicles) has sparked much interest as potential biomarkers for the non-invasive analysis of disease. Here we use the Illumina Genome Analyzer to determine the comprehensive array of nucleic acid reads present in urinary microv...

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Veröffentlicht in:	PloS one 2014-05, Vol.9 (5), p.e96094-e96094
Hauptverfasser:	Miranda, Kevin C, Bond, Daniel T, Levin, Joshua Z, Adiconis, Xian, Sivachenko, Andrey, Russ, Carsten, Brown, Dennis, Nusbaum, Chad, Russo, Leileata M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alignment Analysis Biology Biology and Life Sciences Biomarkers Biopsy Bladder Chromosome Mapping Cloning Collecting duct Deoxyribonuclease Deoxyribonucleic acid DNA Exosomes Exosomes - genetics Gene sequencing Genes Genitourinary tract Genome, Human - genetics Genomes Genomics High-Throughput Nucleotide Sequencing - methods Humans Kidneys Male Medical schools Medicine and Health Sciences MicroRNAs Multiprocessing Nephrology Non-coding RNA Nucleic acids Nucleotide sequence Oligonucleotide Array Sequence Analysis - methods Prostate Prostate cancer Proteins Repetitive Sequences, Nucleic Acid - genetics Ribonuclease Ribonucleic acid RNA RNA - chemistry RNA - genetics RNA - urine RNA, Ribosomal - chemistry RNA, Ribosomal - genetics RNA, Ribosomal - urine RNA, Untranslated - chemistry RNA, Untranslated - genetics RNA, Untranslated - urine rRNA Satellite RNA snRNA Transcription Transcriptome Transfer RNA tRNA Urinary bladder Urine Urogenital system Urogenital System - metabolism
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