The screening research of anti-inflammatory bioactive markers from different flowering phases of Flos Lonicerae Japonicae
Flos Lonicerae Japonicae (FLJ) is an important cash crop in eastern Asia, and it is an anti-inflammatory Traditional Chinese Medicine. There are large variations in the quality of the marketed FLJ products. To find marker ingredients useful for quality control, a tandem technology integrating ultra-...
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| Veröffentlicht in: | PloS one 2014-05, Vol.9 (5), p.e96214-e96214 |
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| creator | Jiang, Min Han, Yan-qi Zhou, Meng-ge Zhao, Hong-zhi Xiao, Xue Hou, Yuan-yuan Gao, Jie Bai, Gang Luo, Guo-an |
| description | Flos Lonicerae Japonicae (FLJ) is an important cash crop in eastern Asia, and it is an anti-inflammatory Traditional Chinese Medicine. There are large variations in the quality of the marketed FLJ products. To find marker ingredients useful for quality control, a tandem technology integrating ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF), principal component analysis (PCA), heat map analysis and hierarchical cluster analysis coupled with a NF-κB luciferase reporter gene assay were used to identify the different ingredients from the green bud, white bud, flowering stage and leaf stages, as well as to screen the anti-inflammatory activity of FLJ compositions. As flowering progressed, the anti-inflammatory effects of FLJ gradually decreased; however, chlorogenic acid, swertiamarin and sweroside should be used to evaluate the quality of FLJ products. |
| doi_str_mv | 10.1371/journal.pone.0096214 |
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There are large variations in the quality of the marketed FLJ products. To find marker ingredients useful for quality control, a tandem technology integrating ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF), principal component analysis (PCA), heat map analysis and hierarchical cluster analysis coupled with a NF-κB luciferase reporter gene assay were used to identify the different ingredients from the green bud, white bud, flowering stage and leaf stages, as well as to screen the anti-inflammatory activity of FLJ compositions. As flowering progressed, the anti-inflammatory effects of FLJ gradually decreased; however, chlorogenic acid, swertiamarin and sweroside should be used to evaluate the quality of FLJ products.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0096214</identifier><identifier>PMID: 24809338</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analgesics ; Anti-inflammatory agents ; Anti-Inflammatory Agents - analysis ; Biology and Life Sciences ; Cash crops ; Chlorogenic acid ; Chromatography ; Chromatography, High Pressure Liquid ; Cluster analysis ; Cytokines ; Flowering ; Flowers - chemistry ; Inflammation ; Ingredients ; Laboratories ; Liquid chromatography ; Lonicera - chemistry ; Lonicera japonica ; Luciferase ; Mass Spectrometry ; Mass spectroscopy ; Medical screening ; Medicine and Health Sciences ; Medicine, Chinese Traditional ; NF-κB protein ; Pharmacy ; Plant Extracts - analysis ; Plant Leaves - chemistry ; Principal components analysis ; Quadrupoles ; Quality control ; Reporter gene ; Rodents ; Traditional Chinese medicine ; Tumor necrosis factor-TNF</subject><ispartof>PloS one, 2014-05, Vol.9 (5), p.e96214-e96214</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Jiang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Jiang et al 2014 Jiang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-b0b2fe82f844dfdf6c7edb1e8db4112b16d98e5756197e0e324c65f2e00b63aa3</citedby><cites>FETCH-LOGICAL-c692t-b0b2fe82f844dfdf6c7edb1e8db4112b16d98e5756197e0e324c65f2e00b63aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014484/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014484/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24809338$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Min</creatorcontrib><creatorcontrib>Han, Yan-qi</creatorcontrib><creatorcontrib>Zhou, Meng-ge</creatorcontrib><creatorcontrib>Zhao, Hong-zhi</creatorcontrib><creatorcontrib>Xiao, Xue</creatorcontrib><creatorcontrib>Hou, Yuan-yuan</creatorcontrib><creatorcontrib>Gao, Jie</creatorcontrib><creatorcontrib>Bai, Gang</creatorcontrib><creatorcontrib>Luo, Guo-an</creatorcontrib><title>The screening research of anti-inflammatory bioactive markers from different flowering phases of Flos Lonicerae Japonicae</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Flos Lonicerae Japonicae (FLJ) is an important cash crop in eastern Asia, and it is an anti-inflammatory Traditional Chinese Medicine. There are large variations in the quality of the marketed FLJ products. To find marker ingredients useful for quality control, a tandem technology integrating ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF), principal component analysis (PCA), heat map analysis and hierarchical cluster analysis coupled with a NF-κB luciferase reporter gene assay were used to identify the different ingredients from the green bud, white bud, flowering stage and leaf stages, as well as to screen the anti-inflammatory activity of FLJ compositions. As flowering progressed, the anti-inflammatory effects of FLJ gradually decreased; however, chlorogenic acid, swertiamarin and sweroside should be used to evaluate the quality of FLJ products.</description><subject>Analgesics</subject><subject>Anti-inflammatory agents</subject><subject>Anti-Inflammatory Agents - analysis</subject><subject>Biology and Life Sciences</subject><subject>Cash crops</subject><subject>Chlorogenic acid</subject><subject>Chromatography</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cluster analysis</subject><subject>Cytokines</subject><subject>Flowering</subject><subject>Flowers - chemistry</subject><subject>Inflammation</subject><subject>Ingredients</subject><subject>Laboratories</subject><subject>Liquid chromatography</subject><subject>Lonicera - chemistry</subject><subject>Lonicera japonica</subject><subject>Luciferase</subject><subject>Mass Spectrometry</subject><subject>Mass spectroscopy</subject><subject>Medical screening</subject><subject>Medicine and Health Sciences</subject><subject>Medicine, Chinese Traditional</subject><subject>NF-κB protein</subject><subject>Pharmacy</subject><subject>Plant Extracts - analysis</subject><subject>Plant Leaves - chemistry</subject><subject>Principal components analysis</subject><subject>Quadrupoles</subject><subject>Quality control</subject><subject>Reporter gene</subject><subject>Rodents</subject><subject>Traditional Chinese medicine</subject><subject>Tumor necrosis factor-TNF</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11v0zAUhiMEYmPwDxBEQkJw0eKvOMkN0jQxKJo0CQa31rFz3LokcWeng_57nLWbWrQL5Atb9vO-x-fYJ8teUjKlvKQfln4deminK9_jlJBaMioeZce05mwiGeGP99ZH2bMYl4QUvJLyaXbEREVqzqvjbHO1wDyagNi7fp4HjAjBLHJvc-gHN3G9baHrYPBhk2vnwQzuBvMOwi8MMbfBd3njrMWA_ZDb1v_GMBqtFhAxjjbnrY_5he-dwQCYf4XVuAZ8nj2x0EZ8sZtPsh_nn67OvkwuLj_Pzk4vJkbWbJhoopnFitlKiMY2VpoSG02xarSglGkqm7rCoiwkrUskyJkwsrAMCdGSA_CT7PXWd5UuonZVi4oWjJVMJmEiZlui8bBUq-BSdhvlwanbDR_mCsLgTIuKM6JragpgYAUQ0FKjaUBUKDUYppPXx120te6wMakqAdoD08OT3i3U3N8oQagQlUgG73YGwV-vMQ6qc9Fg20KPfn17by5IxYsyoW_-QR_ObkfNISWQ3tOnuGY0VaeCVpKLoqoTNX2ASqPBzpn0xaxL-weC9weCxAz4Z5jDOkY1-_7t_9nLn4fs2z12gdAOi-jb9eB8Hw9BsQVN8DEGtPdFpkSNHXJXDTV2iNp1SJK92n-ge9FdS_C_ZEYOcQ</recordid><startdate>20140508</startdate><enddate>20140508</enddate><creator>Jiang, Min</creator><creator>Han, Yan-qi</creator><creator>Zhou, Meng-ge</creator><creator>Zhao, Hong-zhi</creator><creator>Xiao, Xue</creator><creator>Hou, Yuan-yuan</creator><creator>Gao, Jie</creator><creator>Bai, Gang</creator><creator>Luo, Guo-an</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140508</creationdate><title>The screening research of anti-inflammatory bioactive markers from different flowering phases of Flos Lonicerae Japonicae</title><author>Jiang, Min ; Han, Yan-qi ; Zhou, Meng-ge ; Zhao, Hong-zhi ; Xiao, Xue ; Hou, Yuan-yuan ; Gao, Jie ; Bai, Gang ; Luo, Guo-an</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-b0b2fe82f844dfdf6c7edb1e8db4112b16d98e5756197e0e324c65f2e00b63aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Analgesics</topic><topic>Anti-inflammatory agents</topic><topic>Anti-Inflammatory Agents - 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There are large variations in the quality of the marketed FLJ products. To find marker ingredients useful for quality control, a tandem technology integrating ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF), principal component analysis (PCA), heat map analysis and hierarchical cluster analysis coupled with a NF-κB luciferase reporter gene assay were used to identify the different ingredients from the green bud, white bud, flowering stage and leaf stages, as well as to screen the anti-inflammatory activity of FLJ compositions. As flowering progressed, the anti-inflammatory effects of FLJ gradually decreased; however, chlorogenic acid, swertiamarin and sweroside should be used to evaluate the quality of FLJ products.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24809338</pmid><doi>10.1371/journal.pone.0096214</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Analgesics Anti-inflammatory agents Anti-Inflammatory Agents - analysis Biology and Life Sciences Cash crops Chlorogenic acid Chromatography Chromatography, High Pressure Liquid Cluster analysis Cytokines Flowering Flowers - chemistry Inflammation Ingredients Laboratories Liquid chromatography Lonicera - chemistry Lonicera japonica Luciferase Mass Spectrometry Mass spectroscopy Medical screening Medicine and Health Sciences Medicine, Chinese Traditional NF-κB protein Pharmacy Plant Extracts - analysis Plant Leaves - chemistry Principal components analysis Quadrupoles Quality control Reporter gene Rodents Traditional Chinese medicine Tumor necrosis factor-TNF |
| title | The screening research of anti-inflammatory bioactive markers from different flowering phases of Flos Lonicerae Japonicae |
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