CX3CR1 is a modifying gene of survival and progression in amyotrophic lateral sclerosis

The objective of this study was to investigate the association of functional variants of the human CX3CR1 gene (Fractalkine receptor) with the risk of Amyotrophic Lateral Sclerosis (ALS), the survival and the progression rate of the disease symptoms in a Spanish ALS cohort. 187 ALS patients (142 spo...

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Veröffentlicht in:	PloS one 2014-05, Vol.9 (5), p.e96528-e96528
Hauptverfasser:	Lopez-Lopez, Alan, Gamez, Josep, Syriani, Emilio, Morales, Miguel, Salvado, Maria, Rodríguez, Manuel J, Mahy, Nicole, Vidal-Taboada, Jose M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alleles Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - mortality Biochemistry Biology and Life Sciences Cardiovascular disease Chemokines Coronary vessels CX3C Chemokine Receptor 1 CX3CR1 protein Development and progression Disease Progression Epidemiology Esclerosi lateral amiotròfica Female Fractalkine Gene therapy Genes Genetic Predisposition to Disease Genotype Genotypes Haplotypes Health risks Hospitals Humans Immune system Malalties neurodegeneratives Male Medical prognosis Medicine Medicine and Health Sciences Middle Aged Molecular biology Motor neurone disease Mutation Neurodegenerative diseases Neurology Pathogenesis Patients Physiology Polymorphism, Single Nucleotide Population Proteins Receptors, Chemokine - genetics Research and Analysis Methods Risk Spain Survival Survival Rate Teràpia genètica
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