TIMI frame count and adverse events in women with no obstructive coronary disease: a pilot study from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE)
TIMI frame count (TFC) predicts outcomes in patients with obstructive coronary artery disease (CAD); it remains unclear whether TFC predicts outcomes in patients without obstructive CAD. TFC was determined in a sample of women with no obstructive CAD enrolled in the Women's Ischemia Syndrome Ev...
Gespeichert in:
| Veröffentlicht in: | PloS one 2014-05, Vol.9 (5), p.e96630 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 5 |
| container_start_page | e96630 |
| container_title | PloS one |
| container_volume | 9 |
| creator | Petersen, John W Johnson, B Delia Kip, Kevin E Anderson, R David Handberg, Eileen M Sharaf, Barry Mehta, Puja K Kelsey, Sheryl F Merz, C Noel Bairey Pepine, Carl J |
| description | TIMI frame count (TFC) predicts outcomes in patients with obstructive coronary artery disease (CAD); it remains unclear whether TFC predicts outcomes in patients without obstructive CAD.
TFC was determined in a sample of women with no obstructive CAD enrolled in the Women's Ischemia Syndrome Evaluation (WISE) study. Because TFC is known to be higher in the left anterior descending artery (LAD), TFC determined in the LAD was divided by 1.7 to provide a corrected TFC (cTFC).
A total of 298 women, with angiograms suitable for TFC analysis and long-term (6-10 year) follow up data, were included in this sub-study. Their age was 55±11 years, most were white (86%), half had a history of smoking, and half had a history of hypertension. Higher resting cTFC was associated with a higher rate of hospitalization for angina (34% in women with a cTFC >35, 15% in women with a cTFC ≤35, P |
| doi_str_mv | 10.1371/journal.pone.0096630 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1521422680</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A418707183</galeid><doaj_id>oai_doaj_org_article_ec24e280a2b443efbc898022dccb75a2</doaj_id><sourcerecordid>A418707183</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-1314518de1771a4976d20d4a73a130c3bae3e97a0d54e509563cc11a4421d8cf3</originalsourceid><addsrcrecordid>eNqNk11rFDEUhgdRbK3-A9FAQduLXfM1X14ItVQ7UC3Yai9DNjmzmzKTrElmtT_I_2mm3Zau9EIGZkLmed_zkZwse0nwlLCSvLt0g7eymy6dhSnGdVEw_CjbJjWjk4Ji9vjeeit7FsIlxjmriuJptkV5hXHJ6u3sz3nzpUGtlz0g5QYbkbQaSb0CHwDBCmwMyFj0y_WQ3iYukHXIzUL0g4pmNaq8s9JfIW0CyADvkURL07mIQhz0VfJ2PYoLQF-PTz42k5DyDc6DRhej5duAmqAW0BuJzq6sTjCgo5XsBhmNs2jvojk72n-ePWllF-DF-ruTff90dH54PDk5_dwcHpxMVFHTOCGM8JxUGkhZEsnrstAUay5LJgnDis0kMKhLiXXOIcd1XjClSCI5JbpSLdvJXt_4LjsXxLrDQZCcEk5pUeFENDeEdvJSLL3pU-nCSSOuN5yfC-mjUR0IUJQDrbCkM84ZtDNV1RWmVCs1K3NJk9eHdbRh1oNWqddedhumm3-sWYi5WwmOCSlT8jvZ3trAu58DhCh6ExR0nbTghuu8x6RrOsba_Qd9uLo1NZepAGNbl-Kq0VQccFKVuCQVS9T0ASo9Oh2jStexNWl_Q7C_IUhMhN9xLocQRHP27f_Z0x-b7Jt77AJkFxfBdcN4c8ImyG9A5V0IHtq7JhMsxmm67YYYp0mspynJXt0_oDvR7fiwv4bNGoU</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1521422680</pqid></control><display><type>article</type><title>TIMI frame count and adverse events in women with no obstructive coronary disease: a pilot study from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE)</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Petersen, John W ; Johnson, B Delia ; Kip, Kevin E ; Anderson, R David ; Handberg, Eileen M ; Sharaf, Barry ; Mehta, Puja K ; Kelsey, Sheryl F ; Merz, C Noel Bairey ; Pepine, Carl J</creator><contributor>Obukhov, Alexander G.</contributor><creatorcontrib>Petersen, John W ; Johnson, B Delia ; Kip, Kevin E ; Anderson, R David ; Handberg, Eileen M ; Sharaf, Barry ; Mehta, Puja K ; Kelsey, Sheryl F ; Merz, C Noel Bairey ; Pepine, Carl J ; Obukhov, Alexander G.</creatorcontrib><description>TIMI frame count (TFC) predicts outcomes in patients with obstructive coronary artery disease (CAD); it remains unclear whether TFC predicts outcomes in patients without obstructive CAD.
TFC was determined in a sample of women with no obstructive CAD enrolled in the Women's Ischemia Syndrome Evaluation (WISE) study. Because TFC is known to be higher in the left anterior descending artery (LAD), TFC determined in the LAD was divided by 1.7 to provide a corrected TFC (cTFC).
A total of 298 women, with angiograms suitable for TFC analysis and long-term (6-10 year) follow up data, were included in this sub-study. Their age was 55±11 years, most were white (86%), half had a history of smoking, and half had a history of hypertension. Higher resting cTFC was associated with a higher rate of hospitalization for angina (34% in women with a cTFC >35, 15% in women with a cTFC ≤35, P<0.001). cTFC provided independent prediction of hospitalization for angina after adjusting for many baseline characteristics. In this cohort, resting cTFC was not predictive of major events (myocardial infarction, heart failure, stroke, or all-cause death), cardiovascular events, all-cause mortality, or cardiovascular mortality.
In women with signs and symptoms of ischemia but no obstructive CAD, resting cTFC provides independent prediction of hospitalization for angina. Larger studies are required to determine if resting TFC is predictive of major events in patients without obstructive coronary artery disease.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0096630</identifier><identifier>PMID: 24800739</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Angina ; Arteries - physiopathology ; Biology and Life Sciences ; Cardiac patients ; Cardiology ; Cardiovascular disease ; Cardiovascular diseases ; Cerebral infarction ; Clinical outcomes ; Consent ; Coronary artery ; Coronary artery disease ; Coronary Disease - physiopathology ; Coronary heart disease ; Coronary vessels ; Evaluation ; Family medical history ; Female ; Flow velocity ; Heart ; Heart attacks ; Heart diseases ; Hospitalization ; Humans ; Hypertension ; Ischemia ; Laboratories ; Medical imaging ; Medical research ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Mortality ; Myocardial infarction ; Myocardial Infarction - physiopathology ; National Heart, Lung, and Blood Institute (U.S.) ; Patients ; Pilot Projects ; Predictions ; Prognosis ; Public health ; Signs and symptoms ; Smoking ; Streisand, Barbra ; United States ; Women ; Women's Health ; Womens health</subject><ispartof>PloS one, 2014-05, Vol.9 (5), p.e96630</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Petersen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Petersen et al 2014 Petersen et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-1314518de1771a4976d20d4a73a130c3bae3e97a0d54e509563cc11a4421d8cf3</citedby><cites>FETCH-LOGICAL-c692t-1314518de1771a4976d20d4a73a130c3bae3e97a0d54e509563cc11a4421d8cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011756/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011756/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24800739$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Obukhov, Alexander G.</contributor><creatorcontrib>Petersen, John W</creatorcontrib><creatorcontrib>Johnson, B Delia</creatorcontrib><creatorcontrib>Kip, Kevin E</creatorcontrib><creatorcontrib>Anderson, R David</creatorcontrib><creatorcontrib>Handberg, Eileen M</creatorcontrib><creatorcontrib>Sharaf, Barry</creatorcontrib><creatorcontrib>Mehta, Puja K</creatorcontrib><creatorcontrib>Kelsey, Sheryl F</creatorcontrib><creatorcontrib>Merz, C Noel Bairey</creatorcontrib><creatorcontrib>Pepine, Carl J</creatorcontrib><title>TIMI frame count and adverse events in women with no obstructive coronary disease: a pilot study from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE)</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>TIMI frame count (TFC) predicts outcomes in patients with obstructive coronary artery disease (CAD); it remains unclear whether TFC predicts outcomes in patients without obstructive CAD.
TFC was determined in a sample of women with no obstructive CAD enrolled in the Women's Ischemia Syndrome Evaluation (WISE) study. Because TFC is known to be higher in the left anterior descending artery (LAD), TFC determined in the LAD was divided by 1.7 to provide a corrected TFC (cTFC).
A total of 298 women, with angiograms suitable for TFC analysis and long-term (6-10 year) follow up data, were included in this sub-study. Their age was 55±11 years, most were white (86%), half had a history of smoking, and half had a history of hypertension. Higher resting cTFC was associated with a higher rate of hospitalization for angina (34% in women with a cTFC >35, 15% in women with a cTFC ≤35, P<0.001). cTFC provided independent prediction of hospitalization for angina after adjusting for many baseline characteristics. In this cohort, resting cTFC was not predictive of major events (myocardial infarction, heart failure, stroke, or all-cause death), cardiovascular events, all-cause mortality, or cardiovascular mortality.
In women with signs and symptoms of ischemia but no obstructive CAD, resting cTFC provides independent prediction of hospitalization for angina. Larger studies are required to determine if resting TFC is predictive of major events in patients without obstructive coronary artery disease.</description><subject>Analysis</subject><subject>Angina</subject><subject>Arteries - physiopathology</subject><subject>Biology and Life Sciences</subject><subject>Cardiac patients</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cerebral infarction</subject><subject>Clinical outcomes</subject><subject>Consent</subject><subject>Coronary artery</subject><subject>Coronary artery disease</subject><subject>Coronary Disease - physiopathology</subject><subject>Coronary heart disease</subject><subject>Coronary vessels</subject><subject>Evaluation</subject><subject>Family medical history</subject><subject>Female</subject><subject>Flow velocity</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Heart diseases</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Ischemia</subject><subject>Laboratories</subject><subject>Medical imaging</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Myocardial infarction</subject><subject>Myocardial Infarction - physiopathology</subject><subject>National Heart, Lung, and Blood Institute (U.S.)</subject><subject>Patients</subject><subject>Pilot Projects</subject><subject>Predictions</subject><subject>Prognosis</subject><subject>Public health</subject><subject>Signs and symptoms</subject><subject>Smoking</subject><subject>Streisand, Barbra</subject><subject>United States</subject><subject>Women</subject><subject>Women's Health</subject><subject>Womens health</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11rFDEUhgdRbK3-A9FAQduLXfM1X14ItVQ7UC3Yai9DNjmzmzKTrElmtT_I_2mm3Zau9EIGZkLmed_zkZwse0nwlLCSvLt0g7eymy6dhSnGdVEw_CjbJjWjk4Ji9vjeeit7FsIlxjmriuJptkV5hXHJ6u3sz3nzpUGtlz0g5QYbkbQaSb0CHwDBCmwMyFj0y_WQ3iYukHXIzUL0g4pmNaq8s9JfIW0CyADvkURL07mIQhz0VfJ2PYoLQF-PTz42k5DyDc6DRhej5duAmqAW0BuJzq6sTjCgo5XsBhmNs2jvojk72n-ePWllF-DF-ruTff90dH54PDk5_dwcHpxMVFHTOCGM8JxUGkhZEsnrstAUay5LJgnDis0kMKhLiXXOIcd1XjClSCI5JbpSLdvJXt_4LjsXxLrDQZCcEk5pUeFENDeEdvJSLL3pU-nCSSOuN5yfC-mjUR0IUJQDrbCkM84ZtDNV1RWmVCs1K3NJk9eHdbRh1oNWqddedhumm3-sWYi5WwmOCSlT8jvZ3trAu58DhCh6ExR0nbTghuu8x6RrOsba_Qd9uLo1NZepAGNbl-Kq0VQccFKVuCQVS9T0ASo9Oh2jStexNWl_Q7C_IUhMhN9xLocQRHP27f_Z0x-b7Jt77AJkFxfBdcN4c8ImyG9A5V0IHtq7JhMsxmm67YYYp0mspynJXt0_oDvR7fiwv4bNGoU</recordid><startdate>20140506</startdate><enddate>20140506</enddate><creator>Petersen, John W</creator><creator>Johnson, B Delia</creator><creator>Kip, Kevin E</creator><creator>Anderson, R David</creator><creator>Handberg, Eileen M</creator><creator>Sharaf, Barry</creator><creator>Mehta, Puja K</creator><creator>Kelsey, Sheryl F</creator><creator>Merz, C Noel Bairey</creator><creator>Pepine, Carl J</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140506</creationdate><title>TIMI frame count and adverse events in women with no obstructive coronary disease: a pilot study from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE)</title><author>Petersen, John W ; Johnson, B Delia ; Kip, Kevin E ; Anderson, R David ; Handberg, Eileen M ; Sharaf, Barry ; Mehta, Puja K ; Kelsey, Sheryl F ; Merz, C Noel Bairey ; Pepine, Carl J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-1314518de1771a4976d20d4a73a130c3bae3e97a0d54e509563cc11a4421d8cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Analysis</topic><topic>Angina</topic><topic>Arteries - physiopathology</topic><topic>Biology and Life Sciences</topic><topic>Cardiac patients</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cerebral infarction</topic><topic>Clinical outcomes</topic><topic>Consent</topic><topic>Coronary artery</topic><topic>Coronary artery disease</topic><topic>Coronary Disease - physiopathology</topic><topic>Coronary heart disease</topic><topic>Coronary vessels</topic><topic>Evaluation</topic><topic>Family medical history</topic><topic>Female</topic><topic>Flow velocity</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Heart diseases</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Ischemia</topic><topic>Laboratories</topic><topic>Medical imaging</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Myocardial infarction</topic><topic>Myocardial Infarction - physiopathology</topic><topic>National Heart, Lung, and Blood Institute (U.S.)</topic><topic>Patients</topic><topic>Pilot Projects</topic><topic>Predictions</topic><topic>Prognosis</topic><topic>Public health</topic><topic>Signs and symptoms</topic><topic>Smoking</topic><topic>Streisand, Barbra</topic><topic>United States</topic><topic>Women</topic><topic>Women's Health</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Petersen, John W</creatorcontrib><creatorcontrib>Johnson, B Delia</creatorcontrib><creatorcontrib>Kip, Kevin E</creatorcontrib><creatorcontrib>Anderson, R David</creatorcontrib><creatorcontrib>Handberg, Eileen M</creatorcontrib><creatorcontrib>Sharaf, Barry</creatorcontrib><creatorcontrib>Mehta, Puja K</creatorcontrib><creatorcontrib>Kelsey, Sheryl F</creatorcontrib><creatorcontrib>Merz, C Noel Bairey</creatorcontrib><creatorcontrib>Pepine, Carl J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Petersen, John W</au><au>Johnson, B Delia</au><au>Kip, Kevin E</au><au>Anderson, R David</au><au>Handberg, Eileen M</au><au>Sharaf, Barry</au><au>Mehta, Puja K</au><au>Kelsey, Sheryl F</au><au>Merz, C Noel Bairey</au><au>Pepine, Carl J</au><au>Obukhov, Alexander G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TIMI frame count and adverse events in women with no obstructive coronary disease: a pilot study from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE)</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-05-06</date><risdate>2014</risdate><volume>9</volume><issue>5</issue><spage>e96630</spage><pages>e96630-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>TIMI frame count (TFC) predicts outcomes in patients with obstructive coronary artery disease (CAD); it remains unclear whether TFC predicts outcomes in patients without obstructive CAD.
TFC was determined in a sample of women with no obstructive CAD enrolled in the Women's Ischemia Syndrome Evaluation (WISE) study. Because TFC is known to be higher in the left anterior descending artery (LAD), TFC determined in the LAD was divided by 1.7 to provide a corrected TFC (cTFC).
A total of 298 women, with angiograms suitable for TFC analysis and long-term (6-10 year) follow up data, were included in this sub-study. Their age was 55±11 years, most were white (86%), half had a history of smoking, and half had a history of hypertension. Higher resting cTFC was associated with a higher rate of hospitalization for angina (34% in women with a cTFC >35, 15% in women with a cTFC ≤35, P<0.001). cTFC provided independent prediction of hospitalization for angina after adjusting for many baseline characteristics. In this cohort, resting cTFC was not predictive of major events (myocardial infarction, heart failure, stroke, or all-cause death), cardiovascular events, all-cause mortality, or cardiovascular mortality.
In women with signs and symptoms of ischemia but no obstructive CAD, resting cTFC provides independent prediction of hospitalization for angina. Larger studies are required to determine if resting TFC is predictive of major events in patients without obstructive coronary artery disease.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24800739</pmid><doi>10.1371/journal.pone.0096630</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-05, Vol.9 (5), p.e96630 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1521422680 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Analysis Angina Arteries - physiopathology Biology and Life Sciences Cardiac patients Cardiology Cardiovascular disease Cardiovascular diseases Cerebral infarction Clinical outcomes Consent Coronary artery Coronary artery disease Coronary Disease - physiopathology Coronary heart disease Coronary vessels Evaluation Family medical history Female Flow velocity Heart Heart attacks Heart diseases Hospitalization Humans Hypertension Ischemia Laboratories Medical imaging Medical research Medicine Medicine and Health Sciences Middle Aged Mortality Myocardial infarction Myocardial Infarction - physiopathology National Heart, Lung, and Blood Institute (U.S.) Patients Pilot Projects Predictions Prognosis Public health Signs and symptoms Smoking Streisand, Barbra United States Women Women's Health Womens health |
| title | TIMI frame count and adverse events in women with no obstructive coronary disease: a pilot study from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T15%3A44%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=TIMI%20frame%20count%20and%20adverse%20events%20in%20women%20with%20no%20obstructive%20coronary%20disease:%20a%20pilot%20study%20from%20the%20NHLBI-sponsored%20Women's%20Ischemia%20Syndrome%20Evaluation%20(WISE)&rft.jtitle=PloS%20one&rft.au=Petersen,%20John%20W&rft.date=2014-05-06&rft.volume=9&rft.issue=5&rft.spage=e96630&rft.pages=e96630-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0096630&rft_dat=%3Cgale_plos_%3EA418707183%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1521422680&rft_id=info:pmid/24800739&rft_galeid=A418707183&rft_doaj_id=oai_doaj_org_article_ec24e280a2b443efbc898022dccb75a2&rfr_iscdi=true |