Comparative characterization of stroma cells and ductal epithelium in chronic pancreatitis and pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extensive stroma being also present in chronic pancreatitis (CP). Using immunohistochemistry, the stroma of CP and PDAC was comprehensively analyzed and correlated with epithelial/carcinoma-related alterations and clinicopathological pat...

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Veröffentlicht in:	PloS one 2014-05, Vol.9 (5), p.e94357
Hauptverfasser:	Helm, Ole, Mennrich, Ruben, Petrick, Domantas, Goebel, Lisa, Freitag-Wolf, Sandra, Röder, Christian, Kalthoff, Holger, Röcken, Christoph, Sipos, Bence, Kabelitz, Dieter, Schäfer, Heiner, Oberg, Hans-Heinrich, Wesch, Daniela, Sebens, Susanne
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adult Age Factors Aged Aged, 80 and over Antigens, Differentiation - metabolism Biology and Life Sciences Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - mortality Carcinoma, Pancreatic Ductal - pathology CD163 antigen CD25 antigen CD3 antigen CD4 antigen CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - pathology CD8 antigen CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - pathology Cell proliferation Cell survival Chemical properties Chemotherapy Chronic Disease Colorectal cancer Comparative analysis Compartments Correlation analysis Disease Disease-Free Survival Epithelium Epithelium - metabolism Epithelium - pathology Female Fibroblasts Foxp3 protein Gene expression Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Immunology Immunoregulation Inflammation Intermediate filament proteins Localization Lymphocytes Lymphocytes T Macrophages Macrophages - metabolism Macrophages - pathology Male Malignancy Medical prognosis Medical research Medicine Medicine and Health Sciences Middle Aged Neoplasm Proteins - biosynthesis Pancreas Pancreatic cancer Pancreatic diseases Pancreatic Ducts - metabolism Pancreatic Ducts - pathology Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Pancreatitis Pancreatitis - metabolism Pancreatitis - mortality Pancreatitis - pathology Pathology Patients Research and Analysis Methods Stroma Stromal Cells - metabolism Stromal Cells - pathology Surgery Survival Rate T cell receptors T cells T-cell receptor Tissue analysis Tissues Tumors
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