Effect of low-magnitude whole-body vibration combined with alendronate in ovariectomized rats: a random controlled osteoporosis prevention study
Alendronate (ALE) is a conventional drug used to treat osteoporosis. Low-magnitude whole-body vibration (WBV) exercise has been developed as a potential treatment for osteoporosis. The aim of this study was to investigate whether low-magnitude WBV could enhance the protective effect of ALE on bone p...
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| Veröffentlicht in: | PloS one 2014-05, Vol.9 (5), p.e96181-e96181 |
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| creator | Chen, Guo-Xian Zheng, Shuai Qin, Shuai Zhong, Zhao-Ming Wu, Xiu-Hua Huang, Zhi-Ping Li, Wei Ding, Ruo-Ting Yu, Hui Chen, Jian-Ting |
| description | Alendronate (ALE) is a conventional drug used to treat osteoporosis. Low-magnitude whole-body vibration (WBV) exercise has been developed as a potential treatment for osteoporosis. The aim of this study was to investigate whether low-magnitude WBV could enhance the protective effect of ALE on bone properties in ovariectomized rats.
A total of 128 Sprague-Dawley rats were randomly divided into five groups (SHAM, OVX+VEH, OVX+WBV, OVX + ALE, OVX+WBV+ALE). The level of WBV applied was 0.3 g at 45-55 Hz for 20 min/day, 5 day/week and for 3 months. ALE was administered in dose of 1 mg/Kg once a week. Every four weeks eight rats from each group were sacrificed and their blood and both tibiae were harvested. The expression of osteocalcin and CTX in serum was measured by enzyme-linked immunosorbent assay (ELISA) and the tibiae were subjected to metaphyseal three-point bending and μCT analysis.
Osteocalcin rose after ovariectomy and was not appreciably changed by either alendronate or WBV alone or in combination. Alendronate treatment significantly prevented an increase in CTX. WBV alone treatment did not alter this effect. Compared with the OVX+WBV group, nearly all tested indices such as the BV/TV, TV apparent, Tb.N, Tb.Th, and Conn.D were higher in the OVX+ALE group at week 12.Compared with the OVX+WBV group, certain tested indices such as BV/TV, TV apparent, Tb.N, and Con.D, were higher in the OVX+WBV+ALE group at week 12. At week 12, tibiae treated with WBV+ALE exhibited a significantly higher Fmax compared to the OVX+VEH group, and a significant difference was also found in energy absorption between the OVX+WBV+ALE and OVX+VEH groups.
Compared with the WBV, ALE was more effective at preventing bone loss and improved the trabecular architecture. However, WBV enhanced the effect of alendronate in ovariectomized rats by inducing further improvements in trabecular architecture. |
| doi_str_mv | 10.1371/journal.pone.0096181 |
| format | Article |
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A total of 128 Sprague-Dawley rats were randomly divided into five groups (SHAM, OVX+VEH, OVX+WBV, OVX + ALE, OVX+WBV+ALE). The level of WBV applied was 0.3 g at 45-55 Hz for 20 min/day, 5 day/week and for 3 months. ALE was administered in dose of 1 mg/Kg once a week. Every four weeks eight rats from each group were sacrificed and their blood and both tibiae were harvested. The expression of osteocalcin and CTX in serum was measured by enzyme-linked immunosorbent assay (ELISA) and the tibiae were subjected to metaphyseal three-point bending and μCT analysis.
Osteocalcin rose after ovariectomy and was not appreciably changed by either alendronate or WBV alone or in combination. Alendronate treatment significantly prevented an increase in CTX. WBV alone treatment did not alter this effect. Compared with the OVX+WBV group, nearly all tested indices such as the BV/TV, TV apparent, Tb.N, Tb.Th, and Conn.D were higher in the OVX+ALE group at week 12.Compared with the OVX+WBV group, certain tested indices such as BV/TV, TV apparent, Tb.N, and Con.D, were higher in the OVX+WBV+ALE group at week 12. At week 12, tibiae treated with WBV+ALE exhibited a significantly higher Fmax compared to the OVX+VEH group, and a significant difference was also found in energy absorption between the OVX+WBV+ALE and OVX+VEH groups.
Compared with the WBV, ALE was more effective at preventing bone loss and improved the trabecular architecture. However, WBV enhanced the effect of alendronate in ovariectomized rats by inducing further improvements in trabecular architecture.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0096181</identifier><identifier>PMID: 24796785</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Activities of daily living ; Alendronic acid ; Animal euthanasia ; Animals ; Architecture ; Back pain ; Back surgery ; Biocompatibility ; Biology and Life Sciences ; Bisphosphonates ; Bone disorder agents ; Bone loss ; Collagen ; Energy absorption ; Enzyme-linked immunosorbent assay ; Enzymes ; Female ; Laboratory animals ; Medical research ; Medicine and Health Sciences ; Osteocalcin ; Osteocalcin - blood ; Osteoporosis ; Osteoporosis - blood ; Osteoporosis - pathology ; Osteoporosis - physiopathology ; Osteoporosis - prevention & control ; Ovariectomy ; Rats ; Rats, Sprague-Dawley ; Research and Analysis Methods ; Rodents ; Studies ; Surgery ; Therapeutic applications ; Vibration</subject><ispartof>PloS one, 2014-05, Vol.9 (5), p.e96181-e96181</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Chen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Chen et al 2014 Chen et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-9229581be52c44d6bd7268645ae663630c5c347db2321155eba915e3bc4593083</citedby><cites>FETCH-LOGICAL-c692t-9229581be52c44d6bd7268645ae663630c5c347db2321155eba915e3bc4593083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010456/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010456/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24796785$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Malaval, Luc</contributor><creatorcontrib>Chen, Guo-Xian</creatorcontrib><creatorcontrib>Zheng, Shuai</creatorcontrib><creatorcontrib>Qin, Shuai</creatorcontrib><creatorcontrib>Zhong, Zhao-Ming</creatorcontrib><creatorcontrib>Wu, Xiu-Hua</creatorcontrib><creatorcontrib>Huang, Zhi-Ping</creatorcontrib><creatorcontrib>Li, Wei</creatorcontrib><creatorcontrib>Ding, Ruo-Ting</creatorcontrib><creatorcontrib>Yu, Hui</creatorcontrib><creatorcontrib>Chen, Jian-Ting</creatorcontrib><title>Effect of low-magnitude whole-body vibration combined with alendronate in ovariectomized rats: a random controlled osteoporosis prevention study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Alendronate (ALE) is a conventional drug used to treat osteoporosis. Low-magnitude whole-body vibration (WBV) exercise has been developed as a potential treatment for osteoporosis. The aim of this study was to investigate whether low-magnitude WBV could enhance the protective effect of ALE on bone properties in ovariectomized rats.
A total of 128 Sprague-Dawley rats were randomly divided into five groups (SHAM, OVX+VEH, OVX+WBV, OVX + ALE, OVX+WBV+ALE). The level of WBV applied was 0.3 g at 45-55 Hz for 20 min/day, 5 day/week and for 3 months. ALE was administered in dose of 1 mg/Kg once a week. Every four weeks eight rats from each group were sacrificed and their blood and both tibiae were harvested. The expression of osteocalcin and CTX in serum was measured by enzyme-linked immunosorbent assay (ELISA) and the tibiae were subjected to metaphyseal three-point bending and μCT analysis.
Osteocalcin rose after ovariectomy and was not appreciably changed by either alendronate or WBV alone or in combination. Alendronate treatment significantly prevented an increase in CTX. WBV alone treatment did not alter this effect. Compared with the OVX+WBV group, nearly all tested indices such as the BV/TV, TV apparent, Tb.N, Tb.Th, and Conn.D were higher in the OVX+ALE group at week 12.Compared with the OVX+WBV group, certain tested indices such as BV/TV, TV apparent, Tb.N, and Con.D, were higher in the OVX+WBV+ALE group at week 12. At week 12, tibiae treated with WBV+ALE exhibited a significantly higher Fmax compared to the OVX+VEH group, and a significant difference was also found in energy absorption between the OVX+WBV+ALE and OVX+VEH groups.
Compared with the WBV, ALE was more effective at preventing bone loss and improved the trabecular architecture. However, WBV enhanced the effect of alendronate in ovariectomized rats by inducing further improvements in trabecular architecture.</description><subject>Activities of daily living</subject><subject>Alendronic acid</subject><subject>Animal euthanasia</subject><subject>Animals</subject><subject>Architecture</subject><subject>Back pain</subject><subject>Back surgery</subject><subject>Biocompatibility</subject><subject>Biology and Life Sciences</subject><subject>Bisphosphonates</subject><subject>Bone disorder agents</subject><subject>Bone loss</subject><subject>Collagen</subject><subject>Energy absorption</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Enzymes</subject><subject>Female</subject><subject>Laboratory animals</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Osteocalcin</subject><subject>Osteocalcin - blood</subject><subject>Osteoporosis</subject><subject>Osteoporosis - blood</subject><subject>Osteoporosis - pathology</subject><subject>Osteoporosis - physiopathology</subject><subject>Osteoporosis - prevention & control</subject><subject>Ovariectomy</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Research and Analysis Methods</subject><subject>Rodents</subject><subject>Studies</subject><subject>Surgery</subject><subject>Therapeutic applications</subject><subject>Vibration</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11rFDEUhgdRbK3-A9EBQfRi13xMMhMvhFKqFgoFv25DMjmzm5JJ1mRm6_or_MlmutvSlV5ILhKS531Pck5OUTzHaI5pjd9dhjF65ear4GGOkOC4wQ-KQywomXGC6MM764PiSUqXCDHacP64OCBVLXjdsMPiz2nXQTuUoStduJr1auHtMBoor5bBwUwHsynXVkc12ODLNvTaejDllR2WpXLgTQxeDVBaX4a1ijZ7hd7-zkiWpPelyrM3oc9SP8TgXD4JaYCwCjEkm8pVhDX4a_eUA2-eFo865RI8281HxfePp99OPs_OLz6dnRyfz1ouyDAThAjWYA2MtFVluDY14Q2vmALOKaeoZS2taqMJJRgzBloJzIDqtmKCooYeFS-3visXktwlM0nMCBJNwxqeibMtYYK6lKtoexU3MigrrzdCXEgVB9s6kEoJILqulaa6aoALMaWa0qbTxBhGsteHXbRR92Da_OKo3J7p_om3S7kIa1khjCo2XebNziCGnyOkQfY2teCc8hDG63tjgXGuaUZf_YPe_7odtchllNZ3IcdtJ1N5XOGmRnVdV5ma30PlYaC3uaTQ2by_J3i7J5jKDr-GhRpTkmdfv_w_e_Fjn319h12CcsMyBTdOHyftg9UWbPP_ShG62yRjJKfGucmGnBpH7hony17cLdCt6KZT6F8r_BWd</recordid><startdate>20140505</startdate><enddate>20140505</enddate><creator>Chen, Guo-Xian</creator><creator>Zheng, Shuai</creator><creator>Qin, Shuai</creator><creator>Zhong, Zhao-Ming</creator><creator>Wu, Xiu-Hua</creator><creator>Huang, Zhi-Ping</creator><creator>Li, Wei</creator><creator>Ding, Ruo-Ting</creator><creator>Yu, Hui</creator><creator>Chen, Jian-Ting</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140505</creationdate><title>Effect of low-magnitude whole-body vibration combined with alendronate in ovariectomized rats: a random controlled osteoporosis prevention study</title><author>Chen, Guo-Xian ; Zheng, Shuai ; Qin, Shuai ; Zhong, Zhao-Ming ; Wu, Xiu-Hua ; Huang, Zhi-Ping ; Li, Wei ; Ding, Ruo-Ting ; Yu, Hui ; Chen, Jian-Ting</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-9229581be52c44d6bd7268645ae663630c5c347db2321155eba915e3bc4593083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Activities of daily living</topic><topic>Alendronic acid</topic><topic>Animal euthanasia</topic><topic>Animals</topic><topic>Architecture</topic><topic>Back pain</topic><topic>Back surgery</topic><topic>Biocompatibility</topic><topic>Biology and Life Sciences</topic><topic>Bisphosphonates</topic><topic>Bone disorder agents</topic><topic>Bone loss</topic><topic>Collagen</topic><topic>Energy absorption</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Enzymes</topic><topic>Female</topic><topic>Laboratory animals</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Osteocalcin</topic><topic>Osteocalcin - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Guo-Xian</au><au>Zheng, Shuai</au><au>Qin, Shuai</au><au>Zhong, Zhao-Ming</au><au>Wu, Xiu-Hua</au><au>Huang, Zhi-Ping</au><au>Li, Wei</au><au>Ding, Ruo-Ting</au><au>Yu, Hui</au><au>Chen, Jian-Ting</au><au>Malaval, Luc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of low-magnitude whole-body vibration combined with alendronate in ovariectomized rats: a random controlled osteoporosis prevention study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-05-05</date><risdate>2014</risdate><volume>9</volume><issue>5</issue><spage>e96181</spage><epage>e96181</epage><pages>e96181-e96181</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Alendronate (ALE) is a conventional drug used to treat osteoporosis. Low-magnitude whole-body vibration (WBV) exercise has been developed as a potential treatment for osteoporosis. The aim of this study was to investigate whether low-magnitude WBV could enhance the protective effect of ALE on bone properties in ovariectomized rats.
A total of 128 Sprague-Dawley rats were randomly divided into five groups (SHAM, OVX+VEH, OVX+WBV, OVX + ALE, OVX+WBV+ALE). The level of WBV applied was 0.3 g at 45-55 Hz for 20 min/day, 5 day/week and for 3 months. ALE was administered in dose of 1 mg/Kg once a week. Every four weeks eight rats from each group were sacrificed and their blood and both tibiae were harvested. The expression of osteocalcin and CTX in serum was measured by enzyme-linked immunosorbent assay (ELISA) and the tibiae were subjected to metaphyseal three-point bending and μCT analysis.
Osteocalcin rose after ovariectomy and was not appreciably changed by either alendronate or WBV alone or in combination. Alendronate treatment significantly prevented an increase in CTX. WBV alone treatment did not alter this effect. Compared with the OVX+WBV group, nearly all tested indices such as the BV/TV, TV apparent, Tb.N, Tb.Th, and Conn.D were higher in the OVX+ALE group at week 12.Compared with the OVX+WBV group, certain tested indices such as BV/TV, TV apparent, Tb.N, and Con.D, were higher in the OVX+WBV+ALE group at week 12. At week 12, tibiae treated with WBV+ALE exhibited a significantly higher Fmax compared to the OVX+VEH group, and a significant difference was also found in energy absorption between the OVX+WBV+ALE and OVX+VEH groups.
Compared with the WBV, ALE was more effective at preventing bone loss and improved the trabecular architecture. However, WBV enhanced the effect of alendronate in ovariectomized rats by inducing further improvements in trabecular architecture.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24796785</pmid><doi>10.1371/journal.pone.0096181</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-05, Vol.9 (5), p.e96181-e96181 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1520988586 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Activities of daily living Alendronic acid Animal euthanasia Animals Architecture Back pain Back surgery Biocompatibility Biology and Life Sciences Bisphosphonates Bone disorder agents Bone loss Collagen Energy absorption Enzyme-linked immunosorbent assay Enzymes Female Laboratory animals Medical research Medicine and Health Sciences Osteocalcin Osteocalcin - blood Osteoporosis Osteoporosis - blood Osteoporosis - pathology Osteoporosis - physiopathology Osteoporosis - prevention & control Ovariectomy Rats Rats, Sprague-Dawley Research and Analysis Methods Rodents Studies Surgery Therapeutic applications Vibration |
| title | Effect of low-magnitude whole-body vibration combined with alendronate in ovariectomized rats: a random controlled osteoporosis prevention study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T06%3A54%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20low-magnitude%20whole-body%20vibration%20combined%20with%20alendronate%20in%20ovariectomized%20rats:%20a%20random%20controlled%20osteoporosis%20prevention%20study&rft.jtitle=PloS%20one&rft.au=Chen,%20Guo-Xian&rft.date=2014-05-05&rft.volume=9&rft.issue=5&rft.spage=e96181&rft.epage=e96181&rft.pages=e96181-e96181&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0096181&rft_dat=%3Cgale_plos_%3EA418707774%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1520988586&rft_id=info:pmid/24796785&rft_galeid=A418707774&rft_doaj_id=oai_doaj_org_article_aa9e2b77ab3b48e6990538338fb2dd52&rfr_iscdi=true |