Routes of delivery for CpG and anti-CD137 for the treatment of orthotopic kidney tumors in mice

We have found previously that the tumor cell lines, Renca (a renal cancer) and MC38 (a colon tumor) which had been injected subcutaneously in mice, could be successfully treated with a combination therapy of an oligodeoxynucleotide (CpG1826) (injected intratumorally) and anti-CD137 antibody (injecte...

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Veröffentlicht in:	PloS one 2014-05, Vol.9 (5), p.e95847
Hauptverfasser:	Westwood, Jennifer A, Potdevin Hunnam, Titaina C U, Pegram, Hollie J, Hicks, Rodney J, Darcy, Phillip K, Kershaw, Michael H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use B cells Biology and Life Sciences Cancer Cancer therapies CD137 antigen Cell Line, Tumor Colon Colon cancer CpG islands Drug Administration Routes Drug Interactions Female Hazards Humans Immune system Immunology Immunotherapy Injection Intravenous administration Kidney cancer Kidney Neoplasms - pathology Kidney Neoplasms - therapy Kidneys Lungs Lymphocytes Lymphocytes T Medical research Medicine and Health Sciences Melanoma Metastases Metastasis Mice Oligodeoxyribonucleotides - administration & dosage Oligodeoxyribonucleotides - pharmacology Oligodeoxyribonucleotides - therapeutic use Oncology R&D Renal cell carcinoma Renal cortex Research & development Research and Analysis Methods Statistical analysis Survival Survival Analysis T cells Therapy TLR9 protein Toll-like receptors Tumor Burden - drug effects Tumor cell lines Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology Tumors Ultrasonic imaging Ultrasound
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