Single rapamycin administration induces prolonged downward shift in defended body weight in rats

Manipulation of body weight set point may be an effective weight loss and maintenance strategy as the homeostatic mechanism governing energy balance remains intact even in obese conditions and counters the effort to lose weight. However, how the set point is determined is not well understood. We sho...

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Veröffentlicht in:	PloS one 2014-05, Vol.9 (5), p.e93691
Hauptverfasser:	Hebert, Mark, Licursi, Maria, Jensen, Brittany, Baker, Ashley, Milway, Steve, Malsbury, Charles, Grant, Virginia L, Adamec, Robert, Hirasawa, Michiru, Blundell, Jacqueline
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Adipose Tissue - drug effects Animals Biology and Life Sciences Body weight Body Weight - drug effects Body weight gain Body weight loss Brain Brain - metabolism Deprivation Desensitization Dextrose Diabetes Dietary restrictions Drug Synergism Eating - drug effects Energy balance Energy Metabolism - drug effects Food Food intake Fuel consumption Glucose Glucose tolerance Homeostasis - drug effects Hyperphagia Injection Injections Intolerance Male Medicine and Health Sciences Obesity Rapamycin Rats Rats, Sprague-Dawley Research and Analysis Methods Rodents Sirolimus - administration & dosage Sirolimus - adverse effects Sirolimus - metabolism Sirolimus - pharmacology Time Factors TOR protein TOR Serine-Threonine Kinases - metabolism Weight control Weight loss Weight reduction
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