Loss of function of TET2 cooperates with constitutively active KIT in murine and human models of mastocytosis

Systemic Mastocytosis (SM) is a clonal disease characterized by abnormal accumulation of mast cells in multiple organs. Clinical presentations of the disease vary widely from indolent to aggressive forms, and to the exceedingly rare mast cell leukemia. Current treatment of aggressive SM and mast cel...

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Veröffentlicht in:	PloS one 2014-05, Vol.9 (5), p.e96209
Hauptverfasser:	De Vita, Serena, Schneider, Rebekka K, Garcia, Michael, Wood, Jenna, Gavillet, Mathilde, Ebert, Benjamin L, Gerbaulet, Alexander, Roers, Axel, Levine, Ross L, Mullally, Ann, Williams, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Apoptosis Azacitidine - analogs & derivatives Azacitidine - therapeutic use Biology and Life Sciences Blotting, Western Bone Marrow Cells - metabolism Bone Marrow Cells - pathology Cancer therapies Cell Line, Tumor Cell Proliferation - genetics Cells (biology) Cells, Cultured Children & youth Cooperation Cytokines Dasatinib Deregulation Disease Disease Models, Animal DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drug Therapy, Combination Enzyme Inhibitors - therapeutic use Epigenetics Esophagus - metabolism Esophagus - pathology Etiology Gene expression Genetic transformation Growth factors Hematology Hospitals Humans Imatinib Immunology Kinases Laboratory animals Leukemia Ligands Mast cell leukemia Mast cells Mast Cells - metabolism Mast Cells - pathology Mastocytosis Mastocytosis, Systemic - drug therapy Mastocytosis, Systemic - genetics Mastocytosis, Systemic - metabolism Medical prognosis Medical schools Medicine Medicine and Health Sciences Mice, Knockout Mice, Transgenic Mutation Mutation, Missense Oncology Organs Pathogenesis Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Protein-tyrosine kinase receptors Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-kit - genetics Proto-Oncogene Proteins c-kit - metabolism Pyrimidines - therapeutic use RNA Interference Skin - metabolism Skin - pathology Stem cells Stomach - metabolism Stomach - pathology Thiazoles - therapeutic use Transformation Transformations (mathematics) Transgenic animals Tyrosine Womens health
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