A human blood-brain barrier transcytosis assay reveals antibody transcytosis influenced by pH-dependent receptor binding

We have adapted an in vitro model of the human blood-brain barrier, the immortalized human cerebral microvascular endothelial cells (hCMEC/D3), to quantitatively measure protein transcytosis. After validating the receptor-mediated transport using transferrin, the system was used to measure transcyto...

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Veröffentlicht in:	PloS one 2014-04, Vol.9 (4), p.e96340-e96340
Hauptverfasser:	Sade, Hadassah, Baumgartner, Claudia, Hugenmatter, Adrian, Moessner, Ekkehard, Freskgård, Per-Ola, Niewoehner, Jens
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Analysis Antibodies Antibodies - immunology Antibodies - metabolism Antigens, CD - immunology Biology and Life Sciences Blood-brain barrier Blood-Brain Barrier - metabolism Brain research Cell Line Chemical properties Compartments Crystal structure Endocytosis Endothelial cells Health aspects Humans Hydrogen ions Hydrogen-Ion Concentration Immunoglobulins Insulin Insulin-like growth factors Ligands Medicine and Health Sciences Microvasculature pH effects Proteins Receptor, IGF Type 1 - immunology Receptors Receptors, Transferrin - immunology Rodents Transcytosis Transferrin Viral antibodies
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