Soluble CEACAM8 interacts with CEACAM1 inhibiting TLR2-triggered immune responses

Lower respiratory tract bacterial infections are characterized by neutrophilic inflammation in the airways. The carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 8 is expressed in and released by human granulocytes. Our study demonstrates that human granulocytes release CEACAM8 in res...

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Veröffentlicht in:	PloS one 2014-04, Vol.9 (4), p.e94106-e94106
Hauptverfasser:	Singer, Bernhard B, Opp, Lena, Heinrich, Annina, Schreiber, Frauke, Binding-Liermann, Ramona, Berrocal-Almanza, Luis Carlos, Heyl, Kerstin A, Müller, Mario M, Weimann, Andreas, Zweigner, Janine, Slevogt, Hortense
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Analysis Animals Antigens Antigens, CD - chemistry Antigens, CD - metabolism Bacteria Bacterial infections Biology and Life Sciences Bronchi - cytology Bronchi - immunology Bronchoalveolar Lavage Fluid Carcinoembryonic antigen Care and treatment CD66 antigen CEACAM1 protein Cell adhesion Cell adhesion & migration Cell adhesion molecules Cell Adhesion Molecules - chemistry Cell Adhesion Molecules - metabolism Cell Count Cell Line Chemokines Cytochalasin D - pharmacology Deoxyribonucleic acid DNA Epithelial cells Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelium GPI-Linked Proteins - chemistry GPI-Linked Proteins - metabolism Granulocytes Granulocytes - cytology Granulocytes - drug effects Health aspects Hospitals Hostages Human behavior Humans Hygiene Immune response Immune system Immunoglobulins Immunology Immunoreceptor tyrosine-based inhibition motif Infections Inflammation Kinases Laboratories Leukocytes (granulocytic) Leukocytes (neutrophilic) Medicine and Health Sciences Moraxella catarrhalis Neutrophils Phosphorylation Physical Sciences Protein Binding Proteins Rats Recruitment Respiratory tract Respiratory tract diseases SHP-1 protein Signal Transduction - drug effects Solubility TLR2 protein TLR9 protein Toll-Like Receptor 2 - metabolism Toll-Like Receptor 9 - metabolism Toll-like receptors Tyrosine
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