Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt/GSK3β signaling pathway

Early brain injury (EBI) plays a key role in the pathogenesis of subarachnoid hemorrhage (SAH). Neuronal apoptosis is involved in the pathological process of EBI. Hydrogen can inhibit neuronal apoptosis and attenuate EBI following SAH. However, the molecular mechanism underlying hydrogen-mediated an...

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Veröffentlicht in:	PloS one 2014-04, Vol.9 (4), p.e96212
Hauptverfasser:	Hong, Yuan, Shao, AnWen, Wang, Jianfeng, Chen, Sheng, Wu, HaiJian, McBride, Devin W, Wu, Qun, Sun, XueJun, Zhang, JianMin
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Alzheimer's disease Animals Apoptosis Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism BAX protein Bcl-2 protein Biology and life sciences Brain Brain damage Brain injury Brain research Caspase Caspase-3 Cerebral Cortex - drug effects Cerebral Cortex - pathology Chromones - pharmacology DNA nucleotidylexotransferase Enzymes Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Head injuries Hemorrhage Hospitals Hydrogen Immunohistochemistry Inhibitors Ischemia Kinases Labelling Male Medical prognosis Medicine Medicine and Health Sciences Morpholines - pharmacology Neurons - drug effects Neurons - pathology Neuroprotection Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Neurosurgery Oxidative stress Pathogenesis Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphorylation Physiology Proteins Proto-Oncogene Proteins c-akt - metabolism Quality Random Allocation Rats Rats, Sprague-Dawley Rodents Signal Transduction Signaling Sodium Chloride - pharmacology Sodium Chloride - therapeutic use Spinal cord injuries Staining Studies Subarachnoid hemorrhage Subarachnoid Hemorrhage - pathology Subarachnoid Hemorrhage - physiopathology Subarachnoid Hemorrhage - prevention & control Surgery Traumatic brain injury Tumor necrosis factor-TNF
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