GPBAR1/TGR5 mediates bile acid-induced cytokine expression in murine Kupffer cells

GPBAR1/TGR5 is a novel plasma membrane-bound G protein-coupled bile acid (BA) receptor. BAs are known to induce the expression of inflammatory cytokines in the liver with unknown mechanism. Here we show that without other external stimuli, TGR5 activation alone induced the expression of interleukin...

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Veröffentlicht in:	PloS one 2014-04, Vol.9 (4), p.e93567
Hauptverfasser:	Lou, Guiyu, Ma, Xiaoxiao, Fu, Xianghui, Meng, Zhipeng, Zhang, Wenyu, Wang, Yan-Dong, Van Ness, Carl, Yu, Donna, Xu, Rongzhen, Huang, Wendong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Activating Transcription Factor 2 - metabolism Activation Analysis Animals Bile Bile Acids and Salts - pharmacology Biology and Life Sciences c-Jun protein Cell Line Chemical properties Cholesterol Cholesterol 7-alpha-Hydroxylase - genetics Cholesterol 7-alpha-Hydroxylase - metabolism Cholic acid Culture Media - pharmacology Cytokines Cytokines - genetics Cytokines - metabolism Deoxycholic acid Deoxyribonucleic acid DNA External stimuli G proteins Gene Expression Regulation - drug effects HEK293 Cells Hepatocytes Hepatocytes - drug effects Hepatocytes - enzymology Humans Hydroxylase IL-1β Inflammation Inflammation Mediators - metabolism Interleukins JNK Mitogen-Activated Protein Kinases - metabolism Kinases Kupffer cells Kupffer Cells - drug effects Kupffer Cells - metabolism Liver Liver - cytology Liver - enzymology Macrophages Membrane proteins Mice, Inbred C57BL Oleanolic Acid - pharmacology Phosphorylation Phosphorylation - drug effects Promoter Regions, Genetic - genetics Protein binding Proto-Oncogene Proteins c-jun - metabolism Receptors, G-Protein-Coupled - metabolism Research and Analysis Methods Rodents Transcription factors Tumor necrosis factor Tumor Necrosis Factor-alpha - genetics Tumor necrosis factor-TNF Tumor necrosis factor-α
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