Unique epitopes recognized by antibodies induced in Chikungunya virus-infected non-human primates: implications for the study of immunopathology and vaccine development

Chikungunya virus (CHIKV) is an Alphavirus that causes chronic and incapacitating arthralgia in humans. Although patient cohort studies have shown the production of CHIKV specific antibodies, the fine specificity of the antibody response against CHIKV is not completely defined. The macaque model of...

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Veröffentlicht in:	PloS one 2014-04, Vol.9 (4), p.e95647-e95647
Hauptverfasser:	Kam, Yiu-Wing, Lee, Wendy W L, Simarmata, Diane, Le Grand, Roger, Tolou, Hugues, Merits, Andres, Roques, Pierre, Ng, Lisa F P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Animals Antibodies Antibodies, Neutralizing - chemistry Antibodies, Neutralizing - immunology Antibodies, Viral - chemistry Antibodies, Viral - immunology Antibody response Antibody Specificity - immunology Antigens, Viral - chemistry Antigens, Viral - immunology Arthralgia Biology and Life Sciences Cell Line Chikungunya Fever - immunology Chikungunya Fever - prevention & control Chikungunya virus Chikungunya virus - immunology Chikungunya virus - metabolism Chronic infection Cloning Coding Disease Models, Animal Epidemics Epitope Mapping Epitopes Epitopes - chemistry Epitopes - immunology Epitopes, B-Lymphocyte - chemistry Epitopes, B-Lymphocyte - immunology Genomes Glycoproteins Humans Immune response Immune system Immunity Immunoglobulin G - immunology Immunoglobulins Immunology Immunopathology Infections Kinetics Laboratory animals Localization Lymphocytes B Macaca fascicularis Measles Medicine and Health Sciences Models, Molecular Neutralization Tests Primates Protein Binding - immunology Protein Conformation Proteins Research and Analysis Methods Studies Target recognition Vaccine development Vaccines Vector-borne diseases Viral Proteins - immunology Viral Proteins - metabolism Viral Vaccines - immunology Virology Virus research Viruses
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