Inhibition of Paracoccidioides lutzii Pb01 isocitrate lyase by the natural compound argentilactone and its semi-synthetic derivatives

The dimorphic fungus Paracoccidioides spp. is responsible for paracoccidioidomycosis, the most prevalent systemic mycosis in Latin America, causing serious public health problems. Adequate treatment of mycotic infections is difficult, since fungi are eukaryotic organisms with a structure and metabol...

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Veröffentlicht in:	PloS one 2014-04, Vol.9 (4), p.e94832-e94832
Hauptverfasser:	Prado, Renata Silva do, Alves, Ricardo Justino, Oliveira, Cecília Maria Alves de, Kato, Lucília, Silva, Roosevelt Alves da, Quintino, Guilherme Oliveira, do Desterro Cunha, Silvio, de Almeida Soares, Célia Maria, Pereira, Maristela
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Antifungal agents Binding Sites Biology and Life Sciences Candida albicans Carbon Carbon sources Derivatives Drug therapy Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Enzymes Fungi Fungicides Glyoxylate cycle Health aspects Health problems Isocitrate lyase Isocitrate Lyase - antagonists & inhibitors Isocitrate Lyase - chemistry Isocitrate Lyase - metabolism Laboratories Lactones - chemistry Lactones - pharmacology Ligands Medicine and Health Sciences Metabolism Microorganisms Molecular Docking Simulation Molecular Dynamics Simulation Mycelium - cytology Mycelium - drug effects Mycoses Mycosis Paracoccidioides Paracoccidioides - drug effects Paracoccidioides - enzymology Paracoccidioides - growth & development Paracoccidioides lutzii Physical Sciences Proteins Public health Solvents - chemistry South American blastomycosis Structural Homology, Protein Thermodynamics Virulence Yeast
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