CXCR4 is dispensable for T cell egress from chronically inflamed skin via the afferent lymph

T cell recirculation through extralymphoid tissues is essential to immune surveillance, host defense and inflammation. In this process, T cells enter the tissue from the blood and subsequently leave via the afferent lymph. In the absence of inflammation, T cells require CCR7 expression to egress fro...

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Veröffentlicht in:	PloS one 2014-04, Vol.9 (4), p.e95626-e95626
Hauptverfasser:	Geherin, Skye A, Wilson, R Paul, Jennrich, Silke, Debes, Gudrun F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive transfer Animals Antigens Biology and Life Sciences CC chemokine receptors CCL21 protein CCR7 protein CD4 antigen CD8 antigen Cell cycle Chemokine CXCL12 - pharmacology Chemokines Chemotactic factors Chemotaxis - drug effects Chronic Disease CXCL12 protein CXCR4 protein Dermatitis Egress Endothelium Experiments Humans Immunosurveillance Infections Inflammation Inflammation - immunology Inflammation - pathology Inflammatory response Laboratories Ligands Lungs Lymph Lymph - drug effects Lymph - immunology Lymphatic system Lymphocytes Lymphocytes T Medical research Medicine and Health Sciences Medicine, Experimental Mice, Inbred C57BL Ovis aries Pharmacology Physiological aspects Receptors Receptors, CCR7 - deficiency Receptors, CCR7 - metabolism Receptors, CXCR4 - antagonists & inhibitors Receptors, CXCR4 - deficiency Receptors, CXCR4 - metabolism Research and Analysis Methods Rodents Sensory neurons Sheep Skin Skin - pathology T cells T-Lymphocytes - drug effects T-Lymphocytes - immunology Tissues Veterinary colleges Veterinary medicine
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