Determination of tissue thermal conductivity by measuring and modeling temperature rise induced in tissue by pulsed focused ultrasound
A tissue thermal conductivity (Ks) is an important parameter which knowledge is essential whenever thermal fields induced in selected organs are predicted. The main objective of this study was to develop an alternative ultrasonic method for determining Ks of tissues in vitro suitable for living tiss...
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| Veröffentlicht in: | PloS one 2014-04, Vol.9 (4), p.e94929-e94929 |
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| description | A tissue thermal conductivity (Ks) is an important parameter which knowledge is essential whenever thermal fields induced in selected organs are predicted. The main objective of this study was to develop an alternative ultrasonic method for determining Ks of tissues in vitro suitable for living tissues. First, the method involves measuring of temperature-time T(t) rises induced in a tested tissue sample by a pulsed focused ultrasound with measured acoustic properties using thermocouples located on the acoustic beam axis. Measurements were performed for 20-cycle tone bursts with a 2 MHz frequency, 0.2 duty-cycle and 3 different initial pressures corresponding to average acoustic powers equal to 0.7 W, 1.4 W and 2.1 W generated from a circular focused transducer with a diameter of 15 mm and f-number of 1.7 in a two-layer system of media: water/beef liver. Measurement results allowed to determine position of maximum heating located inside the beef liver. It was found that this position is at the same axial distance from the source as the maximum peak-peak pressure calculated for each nonlinear beam produced in the two-layer system of media. Then, the method involves modeling of T(t) at the point of maximum heating and fitting it to the experimental data by adjusting Ks. The averaged value of Ks determined by the proposed method was found to be 0.5±0.02 W/(m·°C) being in good agreement with values determined by other methods. The proposed method is suitable for determining Ks of some animal tissues in vivo (for example a rat liver). |
| doi_str_mv | 10.1371/journal.pone.0094929 |
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The main objective of this study was to develop an alternative ultrasonic method for determining Ks of tissues in vitro suitable for living tissues. First, the method involves measuring of temperature-time T(t) rises induced in a tested tissue sample by a pulsed focused ultrasound with measured acoustic properties using thermocouples located on the acoustic beam axis. Measurements were performed for 20-cycle tone bursts with a 2 MHz frequency, 0.2 duty-cycle and 3 different initial pressures corresponding to average acoustic powers equal to 0.7 W, 1.4 W and 2.1 W generated from a circular focused transducer with a diameter of 15 mm and f-number of 1.7 in a two-layer system of media: water/beef liver. Measurement results allowed to determine position of maximum heating located inside the beef liver. It was found that this position is at the same axial distance from the source as the maximum peak-peak pressure calculated for each nonlinear beam produced in the two-layer system of media. Then, the method involves modeling of T(t) at the point of maximum heating and fitting it to the experimental data by adjusting Ks. The averaged value of Ks determined by the proposed method was found to be 0.5±0.02 W/(m·°C) being in good agreement with values determined by other methods. The proposed method is suitable for determining Ks of some animal tissues in vivo (for example a rat liver).</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0094929</identifier><identifier>PMID: 24743838</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acoustic measurement ; Acoustic properties ; Acoustics ; Animal tissues ; Animals ; Beef ; Biology and Life Sciences ; Care and treatment ; Conduction ; Diagnosis ; Engineering and Technology ; Heat ; Heat conductivity ; Heat transfer ; Heating ; In vivo methods and tests ; Liver ; Liver diseases ; Measurement techniques ; Medicine and Health Sciences ; Modelling ; Models, Theoretical ; Organs ; Peak pressure ; Physical Sciences ; Position measurement ; Propagation ; Rats ; Temperature ; Temperature effects ; Temperature rise ; Thermal conductivity ; Thermocouples ; Ultrasonic imaging ; Ultrasonic testing ; Ultrasonography - instrumentation ; Ultrasonography - methods ; Ultrasound</subject><ispartof>PloS one, 2014-04, Vol.9 (4), p.e94929-e94929</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Kujawska et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Kujawska et al 2014 Kujawska et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-94aace97987a50839a567dc514d4e4cfa23cf5fe81505c8ffd6465bf9337e0bb3</citedby><cites>FETCH-LOGICAL-c692t-94aace97987a50839a567dc514d4e4cfa23cf5fe81505c8ffd6465bf9337e0bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990557/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990557/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24743838$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Wright, Neil T.</contributor><creatorcontrib>Kujawska, Tamara</creatorcontrib><creatorcontrib>Secomski, Wojciech</creatorcontrib><creatorcontrib>Kruglenko, Eleonora</creatorcontrib><creatorcontrib>Krawczyk, Kazimierz</creatorcontrib><creatorcontrib>Nowicki, Andrzej</creatorcontrib><title>Determination of tissue thermal conductivity by measuring and modeling temperature rise induced in tissue by pulsed focused ultrasound</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>A tissue thermal conductivity (Ks) is an important parameter which knowledge is essential whenever thermal fields induced in selected organs are predicted. The main objective of this study was to develop an alternative ultrasonic method for determining Ks of tissues in vitro suitable for living tissues. First, the method involves measuring of temperature-time T(t) rises induced in a tested tissue sample by a pulsed focused ultrasound with measured acoustic properties using thermocouples located on the acoustic beam axis. Measurements were performed for 20-cycle tone bursts with a 2 MHz frequency, 0.2 duty-cycle and 3 different initial pressures corresponding to average acoustic powers equal to 0.7 W, 1.4 W and 2.1 W generated from a circular focused transducer with a diameter of 15 mm and f-number of 1.7 in a two-layer system of media: water/beef liver. Measurement results allowed to determine position of maximum heating located inside the beef liver. It was found that this position is at the same axial distance from the source as the maximum peak-peak pressure calculated for each nonlinear beam produced in the two-layer system of media. Then, the method involves modeling of T(t) at the point of maximum heating and fitting it to the experimental data by adjusting Ks. The averaged value of Ks determined by the proposed method was found to be 0.5±0.02 W/(m·°C) being in good agreement with values determined by other methods. The proposed method is suitable for determining Ks of some animal tissues in vivo (for example a rat liver).</description><subject>Acoustic measurement</subject><subject>Acoustic properties</subject><subject>Acoustics</subject><subject>Animal tissues</subject><subject>Animals</subject><subject>Beef</subject><subject>Biology and Life Sciences</subject><subject>Care and treatment</subject><subject>Conduction</subject><subject>Diagnosis</subject><subject>Engineering and Technology</subject><subject>Heat</subject><subject>Heat conductivity</subject><subject>Heat transfer</subject><subject>Heating</subject><subject>In vivo methods and tests</subject><subject>Liver</subject><subject>Liver diseases</subject><subject>Measurement techniques</subject><subject>Medicine and Health Sciences</subject><subject>Modelling</subject><subject>Models, Theoretical</subject><subject>Organs</subject><subject>Peak pressure</subject><subject>Physical Sciences</subject><subject>Position measurement</subject><subject>Propagation</subject><subject>Rats</subject><subject>Temperature</subject><subject>Temperature effects</subject><subject>Temperature rise</subject><subject>Thermal conductivity</subject><subject>Thermocouples</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonic testing</subject><subject>Ultrasonography - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kujawska, Tamara</au><au>Secomski, Wojciech</au><au>Kruglenko, Eleonora</au><au>Krawczyk, Kazimierz</au><au>Nowicki, Andrzej</au><au>Wright, Neil T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of tissue thermal conductivity by measuring and modeling temperature rise induced in tissue by pulsed focused ultrasound</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>9</volume><issue>4</issue><spage>e94929</spage><epage>e94929</epage><pages>e94929-e94929</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>A tissue thermal conductivity (Ks) is an important parameter which knowledge is essential whenever thermal fields induced in selected organs are predicted. The main objective of this study was to develop an alternative ultrasonic method for determining Ks of tissues in vitro suitable for living tissues. First, the method involves measuring of temperature-time T(t) rises induced in a tested tissue sample by a pulsed focused ultrasound with measured acoustic properties using thermocouples located on the acoustic beam axis. Measurements were performed for 20-cycle tone bursts with a 2 MHz frequency, 0.2 duty-cycle and 3 different initial pressures corresponding to average acoustic powers equal to 0.7 W, 1.4 W and 2.1 W generated from a circular focused transducer with a diameter of 15 mm and f-number of 1.7 in a two-layer system of media: water/beef liver. Measurement results allowed to determine position of maximum heating located inside the beef liver. It was found that this position is at the same axial distance from the source as the maximum peak-peak pressure calculated for each nonlinear beam produced in the two-layer system of media. Then, the method involves modeling of T(t) at the point of maximum heating and fitting it to the experimental data by adjusting Ks. The averaged value of Ks determined by the proposed method was found to be 0.5±0.02 W/(m·°C) being in good agreement with values determined by other methods. The proposed method is suitable for determining Ks of some animal tissues in vivo (for example a rat liver).</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24743838</pmid><doi>10.1371/journal.pone.0094929</doi><oa>free_for_read</oa></addata></record> |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acoustic measurement Acoustic properties Acoustics Animal tissues Animals Beef Biology and Life Sciences Care and treatment Conduction Diagnosis Engineering and Technology Heat Heat conductivity Heat transfer Heating In vivo methods and tests Liver Liver diseases Measurement techniques Medicine and Health Sciences Modelling Models, Theoretical Organs Peak pressure Physical Sciences Position measurement Propagation Rats Temperature Temperature effects Temperature rise Thermal conductivity Thermocouples Ultrasonic imaging Ultrasonic testing Ultrasonography - instrumentation Ultrasonography - methods Ultrasound |
| title | Determination of tissue thermal conductivity by measuring and modeling temperature rise induced in tissue by pulsed focused ultrasound |
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