Sonic Hedgehog activation is implicated in diosgenin-induced megakaryocytic differentiation of human erythroleukemia cells

Differentiation therapy is a means to treat cancer and is induced by different agents with low toxicity and more specificity than traditional ones. Diosgenin, a plant steroid, is able to induce megakaryocytic differentiation or apoptosis in human HEL erythroleukemia cells in a dose-dependent manner....

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Veröffentlicht in:	PloS one 2014-04, Vol.9 (4), p.e95016
Hauptverfasser:	Ghezali, Lamia, Liagre, Bertrand, Limami, Youness, Beneytout, Jean-Louis, Leger, David Yannick
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Acute leukemia Analysis Apoptosis Biology and life sciences Blotting, Western Bone marrow Cancer Cancer cells Cancer therapies Care and treatment Cell differentiation Cell Differentiation - drug effects Cell Differentiation - genetics Cell Line, Tumor Cellular Biology Differentiation Diosgenin - pharmacology Erythroleukemia Gene Expression Regulation, Leukemic - drug effects Genetic aspects Hedgehog protein Hedgehog Proteins - genetics Hedgehog Proteins - metabolism Humans Inhibition Leukemia Leukemia, Erythroblastic, Acute - genetics Leukemia, Erythroblastic, Acute - metabolism Leukemia, Erythroblastic, Acute - pathology Life Sciences Medicine and Health Sciences Megakaryocytes - drug effects Megakaryocytes - metabolism Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Penicillin Phosphorylation - drug effects Physiological aspects Proteins Pyridines - pharmacology Pyrimidines - pharmacology Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA Interference Signal transduction Signal Transduction - drug effects Signal Transduction - genetics Smoothened Receptor Stem cells Time Factors Toxicity Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Zinc Finger Protein GLI1
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