Interleukin-7 and Toll-like receptor 7 induce synergistic B cell and T cell activation

To investigate the potential synergy of IL-7-driven T cell-dependent and TLR7-mediated B cell activation and to assess the additive effects of monocyte/macrophages in this respect. Isolated CD19 B cells and CD4 T cells from healthy donors were co-cultured with TLR7 agonist (TLR7A, Gardiquimod), IL-7...

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Veröffentlicht in:	PloS one 2014-04, Vol.9 (4), p.e94756-e94756
Hauptverfasser:	Bikker, Angela, Kruize, Aike A, van der Wurff-Jacobs, Kim M G, Peters, Rogier P, Kleinjan, Marije, Redegeld, Frank, de Jager, Wilco, Lafeber, Floris P J G, van Roon, Joël A G
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoquinolines - immunology Aminoquinolines - pharmacology Analysis Antigens Antigens, CD19 - immunology Antigens, CD19 - metabolism Autoimmune diseases B-Lymphocytes - immunology B-Lymphocytes - metabolism Biology and Life Sciences CD14 antigen CD19 antigen CD25 antigen CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cell activation Cell Proliferation - drug effects Cells, Cultured Coculture Techniques Cooperation Cytokines Cytokines - immunology Cytokines - metabolism Dendritic cells Disease Distribution Enzyme-Linked Immunosorbent Assay Flow Cytometry Helper cells Histocompatibility antigen HLA HLA-DR Antigens - immunology HLA-DR Antigens - metabolism Humans Imidazoles - immunology Imidazoles - pharmacology Immunoglobulin G - immunology Immunoglobulin G - metabolism Immunoglobulin M - immunology Immunoglobulin M - metabolism Immunoglobulins Immunology Inflammatory bowel disease Interleukin 22 Interleukin 7 Interleukin-7 - immunology Interleukin-7 - pharmacology Interleukins Ki-67 Antigen - immunology Ki-67 Antigen - metabolism Lupus Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Lymphocyte receptors Lymphocytes Lymphocytes B Lymphocytes T Macrophages Monocytes Pharmaceutical sciences Research and Analysis Methods Rheumatoid arthritis Rheumatology Studies Systemic lupus erythematosus T cell receptors T-Lymphocytes - immunology T-Lymphocytes - metabolism Thymidine TLR7 protein Toll-Like Receptor 7 - agonists Toll-Like Receptor 7 - immunology Toll-Like Receptor 7 - metabolism Toll-like receptors γ-Interferon
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