The rate of nonallelic homologous recombination in males is highly variable, correlated between monozygotic twins and independent of age

Nonallelic homologous recombination (NAHR) between highly similar duplicated sequences generates chromosomal deletions, duplications and inversions, which can cause diverse genetic disorders. Little is known about interindividual variation in NAHR rates and the factors that influence this. We estima...

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Veröffentlicht in:	PLoS genetics 2014-03, Vol.10 (3), p.e1004195
Hauptverfasser:	MacArthur, Jacqueline A L, Spector, Timothy D, Lindsay, Sarah J, Mangino, Massimo, Gill, Raj, Small, Kerrin S, Hurles, Matthew E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Aged Alcohol use Alleles Biology Biomedical research Body mass index Chromosome Deletion Chromosomes Deoxyribonucleic acid DNA DNA sequencing Gene Duplication Genetic disorders Genetic recombination Genetic research Homologous Recombination - genetics Humans INDEL Mutation - genetics Male Males Medical research Middle Aged Neurofibromatosis 1 - genetics Nucleotide sequencing Physiological aspects Regression analysis Sequence Deletion - genetics Sperm Spermatozoa Twins, Monozygotic - genetics
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