Viral quasispecies assembly via maximal clique enumeration

Virus populations can display high genetic diversity within individual hosts. The intra-host collection of viral haplotypes, called viral quasispecies, is an important determinant of virulence, pathogenesis, and treatment outcome. We present HaploClique, a computational approach to reconstruct the s...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PLoS computational biology 2014-03, Vol.10 (3), p.e1003515
Hauptverfasser:	Töpfer, Armin, Marschall, Tobias, Bull, Rowena A, Luciani, Fabio, Schönhuth, Alexander, Beerenwinkel, Niko
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological diversity Biology CD8-Positive T-Lymphocytes - virology Computational Biology - methods Drug resistance Experiments Gene Deletion Genetic diversity Genetic research Genetic Variation Genome, Viral Genomes Haplotypes Hepacivirus - genetics Hepatitis High-Throughput Nucleotide Sequencing HIV Host-parasite relationships Human immunodeficiency virus Humans Microbiological research Models, Statistical Mutation Pathogenesis Population Probability Sequence Alignment Sequence Analysis, DNA - methods Software Virulence (Microbiology) Viruses Viruses - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!