Structural and functional characterization of a complex between the acidic transactivation domain of EBNA2 and the Tfb1/p62 subunit of TFIIH

Infection with the Epstein-Barr virus (EBV) can lead to a number of human diseases including Hodgkin's and Burkitt's lymphomas. The development of these EBV-linked diseases is associated with the presence of nine viral latent proteins, including the nuclear antigen 2 (EBNA2). The EBNA2 pro...

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Veröffentlicht in:	PLoS pathogens 2014-03, Vol.10 (3), p.e1004042-e1004042
Hauptverfasser:	Chabot, Philippe R, Raiola, Luca, Lussier-Price, Mathieu, Morse, Thomas, Arseneault, Genevieve, Archambault, Jacques, Omichinski, James G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen-antibody reactions Biology and Life Sciences Cancer Epstein-Barr virus Epstein-Barr Virus Infections - metabolism Epstein-Barr Virus Nuclear Antigens - chemistry Epstein-Barr Virus Nuclear Antigens - metabolism Gene expression Genetic aspects Genetic research Genetic transcription Health aspects Herpesvirus 4, Human - metabolism Host-parasite relationships Host-Pathogen Interactions - physiology Humans Infections Medical research Microbiological research NMR Nuclear magnetic resonance Nuclear Magnetic Resonance, Biomolecular Physical Sciences Protein Structure, Tertiary Proteins Spectrum analysis Structure-Activity Relationship Studies Transcription Factor TFIIH - chemistry Transcription Factor TFIIH - metabolism Transcription factors Transcriptional Activation Viral Proteins - chemistry Viral Proteins - metabolism
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