Thyroid function and body weight: a community-based longitudinal study
Body weight and overt thyroid dysfunction are associated. Cross-sectional population-based studies have repeatedly found that thyroid hormone levels, even within the normal reference range, might be associated with body weight. However, for longitudinal data, the association is less clear. Thus, we...
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| description | Body weight and overt thyroid dysfunction are associated. Cross-sectional population-based studies have repeatedly found that thyroid hormone levels, even within the normal reference range, might be associated with body weight. However, for longitudinal data, the association is less clear. Thus, we tested the association between serum thyrotropin (TSH) and body weight in a community-based sample of adult persons followed for 11 years.
A random sample of 4,649 persons aged 18-65 years from a general population participated in the DanThyr study in 1997-8. We included 2,102 individuals who participated at 11-year follow-up, without current or former treatment for thyroid disease and with measurements of TSH and weight at both examinations. Multiple linear regression models were used, stratified by sex and adjusted for age, smoking status, and leisure time physical activity.
Baseline TSH concentration was not associated with change in weight (women, P = 0.17; men, P = 0.72), and baseline body mass index (BMI) was not associated with change in TSH (women, P = 0.21; men, P = 0.85). Change in serum TSH and change in weight were significantly associated in both sexes. Weight increased by 0.3 kg (95% confidence interval [CI] 0.1, 0.4, P = 0.005) in women and 0.8 kg (95% CI 0.1, 1.4, P = 0.02) in men for every one unit TSH (mU/L) increase.
TSH levels were not a determinant of future weight changes, and BMI was not a determinant for TSH changes, but an association between weight change and TSH change was present. |
| doi_str_mv | 10.1371/journal.pone.0093515 |
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A random sample of 4,649 persons aged 18-65 years from a general population participated in the DanThyr study in 1997-8. We included 2,102 individuals who participated at 11-year follow-up, without current or former treatment for thyroid disease and with measurements of TSH and weight at both examinations. Multiple linear regression models were used, stratified by sex and adjusted for age, smoking status, and leisure time physical activity.
Baseline TSH concentration was not associated with change in weight (women, P = 0.17; men, P = 0.72), and baseline body mass index (BMI) was not associated with change in TSH (women, P = 0.21; men, P = 0.85). Change in serum TSH and change in weight were significantly associated in both sexes. Weight increased by 0.3 kg (95% confidence interval [CI] 0.1, 0.4, P = 0.005) in women and 0.8 kg (95% CI 0.1, 1.4, P = 0.02) in men for every one unit TSH (mU/L) increase.
TSH levels were not a determinant of future weight changes, and BMI was not a determinant for TSH changes, but an association between weight change and TSH change was present.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0093515</identifier><identifier>PMID: 24728291</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Aged ; Analysis ; Biology and Life Sciences ; Body mass ; Body mass index ; Body size ; Body weight ; Body Weight - physiology ; Care and treatment ; Communities ; Confidence intervals ; Correlation analysis ; Cross-Sectional Studies ; Diagnosis ; Drug dosages ; Endocrinology ; Exercise ; Female ; Gastrointestinal surgery ; Health aspects ; Hormones ; Hospitals ; Humans ; Hyperthyroidism ; Hypothyroidism ; Iodine ; Longitudinal Studies ; Male ; Medical treatment ; Medicine and Health Sciences ; Men ; Metabolism ; Middle Aged ; Nutrition research ; Physical activity ; Population studies ; Regression analysis ; Regression models ; Research and Analysis Methods ; Risk factors ; Smoking ; Statistical analysis ; Studies ; Thermogenesis ; Thyroid ; Thyroid diseases ; Thyroid Gland - metabolism ; Thyroid-stimulating hormone ; Thyrotropin ; Thyrotropin - blood ; Urine ; Weight control ; Young Adult</subject><ispartof>PloS one, 2014-04, Vol.9 (4), p.e93515-e93515</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Bjergved et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Bjergved et al 2014 Bjergved et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-1117d15199567afce4783677cc98246142f22bf8a385d64ee6d43a9d922ca18f3</citedby><cites>FETCH-LOGICAL-c758t-1117d15199567afce4783677cc98246142f22bf8a385d64ee6d43a9d922ca18f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984087/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984087/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24728291$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bjergved, Lena</creatorcontrib><creatorcontrib>Jørgensen, Torben</creatorcontrib><creatorcontrib>Perrild, Hans</creatorcontrib><creatorcontrib>Laurberg, Peter</creatorcontrib><creatorcontrib>Krejbjerg, Anne</creatorcontrib><creatorcontrib>Ovesen, Lars</creatorcontrib><creatorcontrib>Rasmussen, Lone Banke</creatorcontrib><creatorcontrib>Knudsen, Nils</creatorcontrib><title>Thyroid function and body weight: a community-based longitudinal study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Body weight and overt thyroid dysfunction are associated. Cross-sectional population-based studies have repeatedly found that thyroid hormone levels, even within the normal reference range, might be associated with body weight. However, for longitudinal data, the association is less clear. Thus, we tested the association between serum thyrotropin (TSH) and body weight in a community-based sample of adult persons followed for 11 years.
A random sample of 4,649 persons aged 18-65 years from a general population participated in the DanThyr study in 1997-8. We included 2,102 individuals who participated at 11-year follow-up, without current or former treatment for thyroid disease and with measurements of TSH and weight at both examinations. Multiple linear regression models were used, stratified by sex and adjusted for age, smoking status, and leisure time physical activity.
Baseline TSH concentration was not associated with change in weight (women, P = 0.17; men, P = 0.72), and baseline body mass index (BMI) was not associated with change in TSH (women, P = 0.21; men, P = 0.85). Change in serum TSH and change in weight were significantly associated in both sexes. Weight increased by 0.3 kg (95% confidence interval [CI] 0.1, 0.4, P = 0.005) in women and 0.8 kg (95% CI 0.1, 1.4, P = 0.02) in men for every one unit TSH (mU/L) increase.
TSH levels were not a determinant of future weight changes, and BMI was not a determinant for TSH changes, but an association between weight change and TSH change was present.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Body weight</subject><subject>Body Weight - physiology</subject><subject>Care and treatment</subject><subject>Communities</subject><subject>Confidence intervals</subject><subject>Correlation analysis</subject><subject>Cross-Sectional Studies</subject><subject>Diagnosis</subject><subject>Drug dosages</subject><subject>Endocrinology</subject><subject>Exercise</subject><subject>Female</subject><subject>Gastrointestinal surgery</subject><subject>Health aspects</subject><subject>Hormones</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hyperthyroidism</subject><subject>Hypothyroidism</subject><subject>Iodine</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical treatment</subject><subject>Medicine and Health Sciences</subject><subject>Men</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Nutrition research</subject><subject>Physical activity</subject><subject>Population studies</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Research and Analysis Methods</subject><subject>Risk factors</subject><subject>Smoking</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Thermogenesis</subject><subject>Thyroid</subject><subject>Thyroid diseases</subject><subject>Thyroid Gland - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bjergved, Lena</au><au>Jørgensen, Torben</au><au>Perrild, Hans</au><au>Laurberg, Peter</au><au>Krejbjerg, Anne</au><au>Ovesen, Lars</au><au>Rasmussen, Lone Banke</au><au>Knudsen, Nils</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thyroid function and body weight: a community-based longitudinal study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>9</volume><issue>4</issue><spage>e93515</spage><epage>e93515</epage><pages>e93515-e93515</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Body weight and overt thyroid dysfunction are associated. Cross-sectional population-based studies have repeatedly found that thyroid hormone levels, even within the normal reference range, might be associated with body weight. However, for longitudinal data, the association is less clear. Thus, we tested the association between serum thyrotropin (TSH) and body weight in a community-based sample of adult persons followed for 11 years.
A random sample of 4,649 persons aged 18-65 years from a general population participated in the DanThyr study in 1997-8. We included 2,102 individuals who participated at 11-year follow-up, without current or former treatment for thyroid disease and with measurements of TSH and weight at both examinations. Multiple linear regression models were used, stratified by sex and adjusted for age, smoking status, and leisure time physical activity.
Baseline TSH concentration was not associated with change in weight (women, P = 0.17; men, P = 0.72), and baseline body mass index (BMI) was not associated with change in TSH (women, P = 0.21; men, P = 0.85). Change in serum TSH and change in weight were significantly associated in both sexes. Weight increased by 0.3 kg (95% confidence interval [CI] 0.1, 0.4, P = 0.005) in women and 0.8 kg (95% CI 0.1, 1.4, P = 0.02) in men for every one unit TSH (mU/L) increase.
TSH levels were not a determinant of future weight changes, and BMI was not a determinant for TSH changes, but an association between weight change and TSH change was present.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24728291</pmid><doi>10.1371/journal.pone.0093515</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-04, Vol.9 (4), p.e93515-e93515 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1515291864 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adolescent Adult Aged Analysis Biology and Life Sciences Body mass Body mass index Body size Body weight Body Weight - physiology Care and treatment Communities Confidence intervals Correlation analysis Cross-Sectional Studies Diagnosis Drug dosages Endocrinology Exercise Female Gastrointestinal surgery Health aspects Hormones Hospitals Humans Hyperthyroidism Hypothyroidism Iodine Longitudinal Studies Male Medical treatment Medicine and Health Sciences Men Metabolism Middle Aged Nutrition research Physical activity Population studies Regression analysis Regression models Research and Analysis Methods Risk factors Smoking Statistical analysis Studies Thermogenesis Thyroid Thyroid diseases Thyroid Gland - metabolism Thyroid-stimulating hormone Thyrotropin Thyrotropin - blood Urine Weight control Young Adult |
| title | Thyroid function and body weight: a community-based longitudinal study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T17%3A09%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Thyroid%20function%20and%20body%20weight:%20a%20community-based%20longitudinal%20study&rft.jtitle=PloS%20one&rft.au=Bjergved,%20Lena&rft.date=2014-04-01&rft.volume=9&rft.issue=4&rft.spage=e93515&rft.epage=e93515&rft.pages=e93515-e93515&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0093515&rft_dat=%3Cgale_plos_%3EA375582833%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1515291864&rft_id=info:pmid/24728291&rft_galeid=A375582833&rft_doaj_id=oai_doaj_org_article_afe7818e06104e1eb35043736db2c47c&rfr_iscdi=true |