The effects of socioeconomic status, clinical factors, and genetic ancestry on pulmonary tuberculosis disease in northeastern Mexico
Diverse socioeconomic and clinical factors influence susceptibility to tuberculosis (TB) disease in Mexico. The role of genetic factors, particularly those that differ between the parental groups that admixed in Mexico, is unclear. The objectives of this study are to identify the socioeconomic and c...
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| description | Diverse socioeconomic and clinical factors influence susceptibility to tuberculosis (TB) disease in Mexico. The role of genetic factors, particularly those that differ between the parental groups that admixed in Mexico, is unclear. The objectives of this study are to identify the socioeconomic and clinical predictors of the transition from latent TB infection (LTBI) to pulmonary TB disease in an urban population in northeastern Mexico, and to examine whether genetic ancestry plays an independent role in this transition. We recruited 97 pulmonary TB disease patients and 97 LTBI individuals from a public hospital in Monterrey, Nuevo León. Socioeconomic and clinical variables were collected from interviews and medical records, and genetic ancestry was estimated for a subset of 142 study participants from 291,917 single nucleotide polymorphisms (SNPs). We examined crude associations between the variables and TB disease status. Significant predictors from crude association tests were analyzed using multivariable logistic regression. We also compared genetic ancestry between LTBI individuals and TB disease patients at 1,314 SNPs in 273 genes from the TB biosystem in the NCBI BioSystems database. In crude association tests, 12 socioeconomic and clinical variables were associated with TB disease. Multivariable logistic regression analyses indicated that marital status, diabetes, and smoking were independently associated with TB status. Genetic ancestry was not associated with TB disease in either crude or multivariable analyses. Separate analyses showed that LTBI individuals recruited from hospital staff had significantly higher European genetic ancestry than LTBI individuals recruited from the clinics and waiting rooms. Genetic ancestry differed between individuals with LTBI and TB disease at SNPs located in two genes in the TB biosystem. These results indicate that Monterrey may be structured with respect to genetic ancestry, and that genetic differences in TB susceptibility in parental populations may contribute to variation in disease susceptibility in the region. |
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The role of genetic factors, particularly those that differ between the parental groups that admixed in Mexico, is unclear. The objectives of this study are to identify the socioeconomic and clinical predictors of the transition from latent TB infection (LTBI) to pulmonary TB disease in an urban population in northeastern Mexico, and to examine whether genetic ancestry plays an independent role in this transition. We recruited 97 pulmonary TB disease patients and 97 LTBI individuals from a public hospital in Monterrey, Nuevo León. Socioeconomic and clinical variables were collected from interviews and medical records, and genetic ancestry was estimated for a subset of 142 study participants from 291,917 single nucleotide polymorphisms (SNPs). We examined crude associations between the variables and TB disease status. Significant predictors from crude association tests were analyzed using multivariable logistic regression. We also compared genetic ancestry between LTBI individuals and TB disease patients at 1,314 SNPs in 273 genes from the TB biosystem in the NCBI BioSystems database. In crude association tests, 12 socioeconomic and clinical variables were associated with TB disease. Multivariable logistic regression analyses indicated that marital status, diabetes, and smoking were independently associated with TB status. Genetic ancestry was not associated with TB disease in either crude or multivariable analyses. Separate analyses showed that LTBI individuals recruited from hospital staff had significantly higher European genetic ancestry than LTBI individuals recruited from the clinics and waiting rooms. Genetic ancestry differed between individuals with LTBI and TB disease at SNPs located in two genes in the TB biosystem. These results indicate that Monterrey may be structured with respect to genetic ancestry, and that genetic differences in TB susceptibility in parental populations may contribute to variation in disease susceptibility in the region.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0094303</identifier><identifier>PMID: 24728409</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Biology and Life Sciences ; Care and treatment ; Diabetes mellitus ; Diagnosis ; Genes ; Genetic aspects ; Genetic factors ; Genetic polymorphisms ; Genome, Human - genetics ; Genotype ; Health aspects ; Humans ; Latent Tuberculosis ; Logistic Models ; Lung diseases ; Medical personnel ; Medical records ; Medicine and Health Sciences ; Mexico - epidemiology ; Multivariate Analysis ; Parenting ; Patients ; Phylogeny ; Polymorphism, Single Nucleotide - genetics ; Regression analysis ; Risk factors ; Sample Size ; Single-nucleotide polymorphism ; Smoking ; Social factors ; Social Sciences ; Socioeconomic Factors ; Socioeconomic status ; Socioeconomics ; Studies ; Systematic review ; Tuberculosis ; Tuberculosis, Pulmonary - epidemiology ; Tuberculosis, Pulmonary - genetics ; Urban populations ; Waiting rooms</subject><ispartof>PloS one, 2014-04, Vol.9 (4), p.e94303-e94303</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Young et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Young et al 2014 Young et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-53763448ec6977281daf6d76ab8392befc8f46b4c71f7384cff1438fad8ffb5c3</citedby><cites>FETCH-LOGICAL-c692t-53763448ec6977281daf6d76ab8392befc8f46b4c71f7384cff1438fad8ffb5c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984129/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984129/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23868,27926,27927,53793,53795</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24728409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Mokrousov, Igor</contributor><creatorcontrib>Young, Bonnie N</creatorcontrib><creatorcontrib>Rendón, Adrian</creatorcontrib><creatorcontrib>Rosas-Taraco, Adrian</creatorcontrib><creatorcontrib>Baker, Jack</creatorcontrib><creatorcontrib>Healy, Meghan</creatorcontrib><creatorcontrib>Gross, Jessica M</creatorcontrib><creatorcontrib>Long, Jeffrey</creatorcontrib><creatorcontrib>Burgos, Marcos</creatorcontrib><creatorcontrib>Hunley, Keith L</creatorcontrib><title>The effects of socioeconomic status, clinical factors, and genetic ancestry on pulmonary tuberculosis disease in northeastern Mexico</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Diverse socioeconomic and clinical factors influence susceptibility to tuberculosis (TB) disease in Mexico. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Young, Bonnie N</au><au>Rendón, Adrian</au><au>Rosas-Taraco, Adrian</au><au>Baker, Jack</au><au>Healy, Meghan</au><au>Gross, Jessica M</au><au>Long, Jeffrey</au><au>Burgos, Marcos</au><au>Hunley, Keith L</au><au>Mokrousov, Igor</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of socioeconomic status, clinical factors, and genetic ancestry on pulmonary tuberculosis disease in northeastern Mexico</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>9</volume><issue>4</issue><spage>e94303</spage><epage>e94303</epage><pages>e94303-e94303</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Diverse socioeconomic and clinical factors influence susceptibility to tuberculosis (TB) disease in Mexico. The role of genetic factors, particularly those that differ between the parental groups that admixed in Mexico, is unclear. The objectives of this study are to identify the socioeconomic and clinical predictors of the transition from latent TB infection (LTBI) to pulmonary TB disease in an urban population in northeastern Mexico, and to examine whether genetic ancestry plays an independent role in this transition. We recruited 97 pulmonary TB disease patients and 97 LTBI individuals from a public hospital in Monterrey, Nuevo León. Socioeconomic and clinical variables were collected from interviews and medical records, and genetic ancestry was estimated for a subset of 142 study participants from 291,917 single nucleotide polymorphisms (SNPs). We examined crude associations between the variables and TB disease status. Significant predictors from crude association tests were analyzed using multivariable logistic regression. We also compared genetic ancestry between LTBI individuals and TB disease patients at 1,314 SNPs in 273 genes from the TB biosystem in the NCBI BioSystems database. In crude association tests, 12 socioeconomic and clinical variables were associated with TB disease. Multivariable logistic regression analyses indicated that marital status, diabetes, and smoking were independently associated with TB status. Genetic ancestry was not associated with TB disease in either crude or multivariable analyses. Separate analyses showed that LTBI individuals recruited from hospital staff had significantly higher European genetic ancestry than LTBI individuals recruited from the clinics and waiting rooms. Genetic ancestry differed between individuals with LTBI and TB disease at SNPs located in two genes in the TB biosystem. These results indicate that Monterrey may be structured with respect to genetic ancestry, and that genetic differences in TB susceptibility in parental populations may contribute to variation in disease susceptibility in the region.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24728409</pmid><doi>10.1371/journal.pone.0094303</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Analysis Biology and Life Sciences Care and treatment Diabetes mellitus Diagnosis Genes Genetic aspects Genetic factors Genetic polymorphisms Genome, Human - genetics Genotype Health aspects Humans Latent Tuberculosis Logistic Models Lung diseases Medical personnel Medical records Medicine and Health Sciences Mexico - epidemiology Multivariate Analysis Parenting Patients Phylogeny Polymorphism, Single Nucleotide - genetics Regression analysis Risk factors Sample Size Single-nucleotide polymorphism Smoking Social factors Social Sciences Socioeconomic Factors Socioeconomic status Socioeconomics Studies Systematic review Tuberculosis Tuberculosis, Pulmonary - epidemiology Tuberculosis, Pulmonary - genetics Urban populations Waiting rooms |
| title | The effects of socioeconomic status, clinical factors, and genetic ancestry on pulmonary tuberculosis disease in northeastern Mexico |
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