IPF fibroblasts are desensitized to type I collagen matrix-induced cell death by suppressing low autophagy via aberrant Akt/mTOR kinases

Idiopathic pulmonary fibrosis (IPF) is a chronic, lethal interstitial lung disease in which the aberrant PTEN/Akt axis plays a major role in conferring a survival phenotype in response to the cell death inducing properties of type I collagen matrix. The underlying mechanism by which IPF fibroblasts...

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Veröffentlicht in:	PloS one 2014-04, Vol.9 (4), p.e94616-e94616
Hauptverfasser:	Nho, Richard Seonghun, Hergert, Polla
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Adenine - analogs & derivatives Adenine - pharmacology AKT protein Apoptosis Autophagy Autophagy - drug effects Biology and life sciences Cell death Cell Line Cell Proliferation Cell Survival Chloroquine - pharmacology Collagen Collagen (type I) Collagen Type I - chemistry Collagen Type I - metabolism Desensitization Enzyme Activation Fibroblasts Fibroblasts - metabolism Fibrosis Genotype & phenotype Health aspects Humans Idiopathic Pulmonary Fibrosis - metabolism Kinases Lung diseases Medicine and Health Sciences Mortality Overexpression Patients Phagocytosis Phagosomes - metabolism Physiological aspects Polymerization Protein kinases Protein Multimerization Proteins Proto-Oncogene Proteins c-akt - metabolism PTEN protein Pulmonary fibrosis Rapamycin Rodents Studies TOR protein TOR Serine-Threonine Kinases - metabolism
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