Comparative analyses of lung transcriptomes in patients with alveolar capillary dysplasia with misalignment of pulmonary veins and in foxf1 heterozygous knockout mice

Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins (ACDMPV) is a developmental disorder of the lungs, primarily affecting their vasculature. FOXF1 haploinsufficiency due to heterozygous genomic deletions and point mutations have been reported in most patients with ACDMPV. The majority...

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Veröffentlicht in:	PloS one 2014-04, Vol.9 (4), p.e94390-e94390
Hauptverfasser:	Sen, Partha, Dharmadhikari, Avinash V, Majewski, Tadeusz, Mohammad, Mahmoud A, Kalin, Tanya V, Zabielska, Joanna, Ren, Xiaomeng, Bray, Molly, Brown, Hannah M, Welty, Stephen, Thevananther, Sundararajah, Langston, Claire, Szafranski, Przemyslaw, Justice, Monica J, Kalinichenko, Vladimir V, Gambin, Anna, Belmont, John, Stankiewicz, Pawel
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Angiogenesis Animals Animals, Newborn Biology Biology and life sciences Cancer Care and treatment Children & youth Comparative analysis Deregulation Developmental disabilities Diagnosis Dysplasia Esophagus Etiology Female Forkhead Transcription Factors - deficiency Forkhead Transcription Factors - genetics Gene expression Gene Expression Profiling Gene Expression Regulation Genes Genes, Lethal Genetics Genomes Haploinsufficiency Hemorrhage Heterozygote Hospitals Humans Hypertension Hypoxia Infant, Newborn Informatics Insulin-like growth factor-binding protein 3 Interleukin 1 Laboratory animals Lethality Lung - abnormalities Lung - blood supply Lung - metabolism Lungs Male Medicine Medicine and Health Sciences Metabolic Networks and Pathways Mice Mice, Knockout Misalignment Mutation Neonates Patients Pediatrics Persistent Fetal Circulation Syndrome - genetics Persistent Fetal Circulation Syndrome - metabolism Physicians Pulmonary Alveoli - abnormalities Pulmonary Alveoli - blood supply Pulmonary Alveoli - metabolism Pulmonary arteries Pulmonary hypertension Pulmonary Veins - abnormalities Pulmonary Veins - metabolism Research and Analysis Methods Rodents Studies Transcription Transcription factors Transcriptome Veins Veins & arteries
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