Hyaluronic acid-modified magnetic iron oxide nanoparticles for MR imaging of surgically induced endometriosis model in rats
Endometriosis is defined as the presence of endometrial tissue outside the uterine, which may affect nearly 60% of women in reproductive age. Deep infiltrating endometriosis (DIE) defined as an endometriotic lesion penetrating into the retroperitoneal space or the wall of the pelvic organs to a dept...
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| creator | Zhang, He Li, Jingchao Sun, Wenjie Hu, Yong Zhang, Guofu Shen, Mingwu Shi, Xiangyang |
| description | Endometriosis is defined as the presence of endometrial tissue outside the uterine, which may affect nearly 60% of women in reproductive age. Deep infiltrating endometriosis (DIE) defined as an endometriotic lesion penetrating into the retroperitoneal space or the wall of the pelvic organs to a depth of at least 5 mm represents the most diagnostic challenge. Herein, we reported the use of hyaluronic acid (HA)-modified magnetic iron oxide nanoparticles (HA-Fe3O4 NPs) for magnetic resonance (MR) imaging of endometriotic lesions in the rodent model. Sixteen endometriotic lesions were surgically induced in eight rats by autologous transplantation. Four weeks after lesion induction, three rats were scanned via MR imaging after tail vein injection of the HA-Fe3O4 NPs. Accordingly, the remaining five mice were sacrificed in the corresponding time points. The ectopic uterine tissues (EUTs) were confirmed by histological analysis. Quantification of Fe in the EUT was also performed by inductively coupled plasma-optical emission spectroscopy. Our results showed that by using the HA-Fe3O4 NPs, the EUTs were able to be visualized via T2-weighted MR imaging at 2 hours post injection, corroborating the Prussian blue staining results. The developed HA-Fe3O4 NPs could be used as negative contrast agents for sensitively detecting endometriosis in a mouse model and may be applied for future hyperthermia treatment of endometriosis. |
| doi_str_mv | 10.1371/journal.pone.0094718 |
| format | Article |
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Deep infiltrating endometriosis (DIE) defined as an endometriotic lesion penetrating into the retroperitoneal space or the wall of the pelvic organs to a depth of at least 5 mm represents the most diagnostic challenge. Herein, we reported the use of hyaluronic acid (HA)-modified magnetic iron oxide nanoparticles (HA-Fe3O4 NPs) for magnetic resonance (MR) imaging of endometriotic lesions in the rodent model. Sixteen endometriotic lesions were surgically induced in eight rats by autologous transplantation. Four weeks after lesion induction, three rats were scanned via MR imaging after tail vein injection of the HA-Fe3O4 NPs. Accordingly, the remaining five mice were sacrificed in the corresponding time points. The ectopic uterine tissues (EUTs) were confirmed by histological analysis. Quantification of Fe in the EUT was also performed by inductively coupled plasma-optical emission spectroscopy. Our results showed that by using the HA-Fe3O4 NPs, the EUTs were able to be visualized via T2-weighted MR imaging at 2 hours post injection, corroborating the Prussian blue staining results. The developed HA-Fe3O4 NPs could be used as negative contrast agents for sensitively detecting endometriosis in a mouse model and may be applied for future hyperthermia treatment of endometriosis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0094718</identifier><identifier>PMID: 24722347</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acids ; Animal tissues ; Animals ; Autografts ; Biocompatibility ; Biology and Life Sciences ; Biomedical materials ; Biotechnology ; Brain cancer ; Chemical engineering ; Chemistry ; Contrast agents ; Contrast Media ; Diagnosis ; Diagnostic systems ; Disease Models, Animal ; Emission spectroscopy ; Endometriosis ; Endometriosis - etiology ; Endometriosis - pathology ; Endometrium ; Endometrium - pathology ; Engineering and Technology ; Female ; Ferric Compounds ; Gynecology ; Hyaluronic Acid ; Hyperthermia ; Inductively coupled plasma ; Injection ; Iron ; Iron oxides ; Laboratory animals ; Lesions ; Magnetic induction ; Magnetic resonance ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Medical research ; Medicine and Health Sciences ; Methods ; Mice ; Morphology ; Nanoparticles ; Nanoparticles - chemistry ; NMR ; Nuclear magnetic resonance ; Obstetrics ; Optical emission spectroscopy ; Organs ; Physical Sciences ; Pigments ; Rats ; Rats, Sprague-Dawley ; Rodents ; Spectroscopy ; Transplantation ; Tumors ; Uterus</subject><ispartof>PloS one, 2014-04, Vol.9 (4), p.e94718</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Zhang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Zhang et al 2014 Zhang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-7668b35467599e45b5090ef51b6a4f319e2dc00cf755850a10c7c03f1944c1543</citedby><cites>FETCH-LOGICAL-c692t-7668b35467599e45b5090ef51b6a4f319e2dc00cf755850a10c7c03f1944c1543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983238/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983238/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24722347$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Xu, Bing</contributor><creatorcontrib>Zhang, He</creatorcontrib><creatorcontrib>Li, Jingchao</creatorcontrib><creatorcontrib>Sun, Wenjie</creatorcontrib><creatorcontrib>Hu, Yong</creatorcontrib><creatorcontrib>Zhang, Guofu</creatorcontrib><creatorcontrib>Shen, Mingwu</creatorcontrib><creatorcontrib>Shi, Xiangyang</creatorcontrib><title>Hyaluronic acid-modified magnetic iron oxide nanoparticles for MR imaging of surgically induced endometriosis model in rats</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Endometriosis is defined as the presence of endometrial tissue outside the uterine, which may affect nearly 60% of women in reproductive age. Deep infiltrating endometriosis (DIE) defined as an endometriotic lesion penetrating into the retroperitoneal space or the wall of the pelvic organs to a depth of at least 5 mm represents the most diagnostic challenge. Herein, we reported the use of hyaluronic acid (HA)-modified magnetic iron oxide nanoparticles (HA-Fe3O4 NPs) for magnetic resonance (MR) imaging of endometriotic lesions in the rodent model. Sixteen endometriotic lesions were surgically induced in eight rats by autologous transplantation. Four weeks after lesion induction, three rats were scanned via MR imaging after tail vein injection of the HA-Fe3O4 NPs. Accordingly, the remaining five mice were sacrificed in the corresponding time points. The ectopic uterine tissues (EUTs) were confirmed by histological analysis. Quantification of Fe in the EUT was also performed by inductively coupled plasma-optical emission spectroscopy. Our results showed that by using the HA-Fe3O4 NPs, the EUTs were able to be visualized via T2-weighted MR imaging at 2 hours post injection, corroborating the Prussian blue staining results. The developed HA-Fe3O4 NPs could be used as negative contrast agents for sensitively detecting endometriosis in a mouse model and may be applied for future hyperthermia treatment of endometriosis.</description><subject>Acids</subject><subject>Animal tissues</subject><subject>Animals</subject><subject>Autografts</subject><subject>Biocompatibility</subject><subject>Biology and Life Sciences</subject><subject>Biomedical materials</subject><subject>Biotechnology</subject><subject>Brain cancer</subject><subject>Chemical engineering</subject><subject>Chemistry</subject><subject>Contrast agents</subject><subject>Contrast Media</subject><subject>Diagnosis</subject><subject>Diagnostic systems</subject><subject>Disease Models, Animal</subject><subject>Emission spectroscopy</subject><subject>Endometriosis</subject><subject>Endometriosis - etiology</subject><subject>Endometriosis - pathology</subject><subject>Endometrium</subject><subject>Endometrium - pathology</subject><subject>Engineering and Technology</subject><subject>Female</subject><subject>Ferric Compounds</subject><subject>Gynecology</subject><subject>Hyaluronic Acid</subject><subject>Hyperthermia</subject><subject>Inductively coupled plasma</subject><subject>Injection</subject><subject>Iron</subject><subject>Iron oxides</subject><subject>Laboratory animals</subject><subject>Lesions</subject><subject>Magnetic induction</subject><subject>Magnetic resonance</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Methods</subject><subject>Mice</subject><subject>Morphology</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Obstetrics</subject><subject>Optical emission spectroscopy</subject><subject>Organs</subject><subject>Physical Sciences</subject><subject>Pigments</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rodents</subject><subject>Spectroscopy</subject><subject>Transplantation</subject><subject>Tumors</subject><subject>Uterus</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl1rFDEUhgdRbK3-A9GAIHgxaz4nMzdCKWoXKoX6cRuy-ZjNMpNskxnp4p83607LDihILhLOec6b5OUtipcILhDh6P0mjNHLbrEN3iwgbChH9aPiFDUElxWG5PHR-aR4ltIGQkbqqnpanGDKMSaUnxa_LneyG2PwTgGpnC77oJ11RoNett4MuexyF4Q7pw3w0oetjLnamQRsiODLDXCZdL4FwYI0xtYp2XU74LweVZYxXofeDNGF5BLI6qbLPRDlkJ4XT6zsknkx7WfF908fv11cllfXn5cX51elqho8lLyq6hVhtOKsaQxlKwYbaCxDq0pSS1BjsFYQKssZqxmUCCquILGooVQhRslZ8fqgu-1CEpNvSSCGaA0bglAmlgdCB7kR25i_FHciSCf-FEJsxfRrUVWMMY0xp1pTVKEVpEgjipHN99sGZ60P023jqjdaGT9E2c1E5x3v1qINPwVpaoJJnQXeTAIx3I4mDf948kS1Mr_KeRuymOpdUuKc7J0gNeeZWvyFykub3qmcHOtyfTbwbjaQmcHcDa0cUxLLrzf_z17_mLNvj9i1kd2wTqEbBxd8moP0AKoYUorGPjiHoNgH_94NsQ--mIKfx14du_4wdJ908huajf4c</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Zhang, He</creator><creator>Li, Jingchao</creator><creator>Sun, Wenjie</creator><creator>Hu, Yong</creator><creator>Zhang, Guofu</creator><creator>Shen, Mingwu</creator><creator>Shi, Xiangyang</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140401</creationdate><title>Hyaluronic acid-modified magnetic iron oxide nanoparticles for MR imaging of surgically induced endometriosis model in rats</title><author>Zhang, He ; Li, Jingchao ; Sun, Wenjie ; Hu, Yong ; Zhang, Guofu ; Shen, Mingwu ; Shi, Xiangyang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-7668b35467599e45b5090ef51b6a4f319e2dc00cf755850a10c7c03f1944c1543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acids</topic><topic>Animal tissues</topic><topic>Animals</topic><topic>Autografts</topic><topic>Biocompatibility</topic><topic>Biology and Life Sciences</topic><topic>Biomedical materials</topic><topic>Biotechnology</topic><topic>Brain cancer</topic><topic>Chemical engineering</topic><topic>Chemistry</topic><topic>Contrast agents</topic><topic>Contrast Media</topic><topic>Diagnosis</topic><topic>Diagnostic systems</topic><topic>Disease Models, Animal</topic><topic>Emission spectroscopy</topic><topic>Endometriosis</topic><topic>Endometriosis - etiology</topic><topic>Endometriosis - pathology</topic><topic>Endometrium</topic><topic>Endometrium - pathology</topic><topic>Engineering and Technology</topic><topic>Female</topic><topic>Ferric Compounds</topic><topic>Gynecology</topic><topic>Hyaluronic Acid</topic><topic>Hyperthermia</topic><topic>Inductively coupled plasma</topic><topic>Injection</topic><topic>Iron</topic><topic>Iron oxides</topic><topic>Laboratory animals</topic><topic>Lesions</topic><topic>Magnetic induction</topic><topic>Magnetic resonance</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Methods</topic><topic>Mice</topic><topic>Morphology</topic><topic>Nanoparticles</topic><topic>Nanoparticles - chemistry</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Obstetrics</topic><topic>Optical emission spectroscopy</topic><topic>Organs</topic><topic>Physical Sciences</topic><topic>Pigments</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rodents</topic><topic>Spectroscopy</topic><topic>Transplantation</topic><topic>Tumors</topic><topic>Uterus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, He</creatorcontrib><creatorcontrib>Li, Jingchao</creatorcontrib><creatorcontrib>Sun, Wenjie</creatorcontrib><creatorcontrib>Hu, Yong</creatorcontrib><creatorcontrib>Zhang, Guofu</creatorcontrib><creatorcontrib>Shen, Mingwu</creatorcontrib><creatorcontrib>Shi, Xiangyang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints in Context (Gale)</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Deep infiltrating endometriosis (DIE) defined as an endometriotic lesion penetrating into the retroperitoneal space or the wall of the pelvic organs to a depth of at least 5 mm represents the most diagnostic challenge. Herein, we reported the use of hyaluronic acid (HA)-modified magnetic iron oxide nanoparticles (HA-Fe3O4 NPs) for magnetic resonance (MR) imaging of endometriotic lesions in the rodent model. Sixteen endometriotic lesions were surgically induced in eight rats by autologous transplantation. Four weeks after lesion induction, three rats were scanned via MR imaging after tail vein injection of the HA-Fe3O4 NPs. Accordingly, the remaining five mice were sacrificed in the corresponding time points. The ectopic uterine tissues (EUTs) were confirmed by histological analysis. Quantification of Fe in the EUT was also performed by inductively coupled plasma-optical emission spectroscopy. Our results showed that by using the HA-Fe3O4 NPs, the EUTs were able to be visualized via T2-weighted MR imaging at 2 hours post injection, corroborating the Prussian blue staining results. The developed HA-Fe3O4 NPs could be used as negative contrast agents for sensitively detecting endometriosis in a mouse model and may be applied for future hyperthermia treatment of endometriosis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24722347</pmid><doi>10.1371/journal.pone.0094718</doi><oa>free_for_read</oa></addata></record> |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acids Animal tissues Animals Autografts Biocompatibility Biology and Life Sciences Biomedical materials Biotechnology Brain cancer Chemical engineering Chemistry Contrast agents Contrast Media Diagnosis Diagnostic systems Disease Models, Animal Emission spectroscopy Endometriosis Endometriosis - etiology Endometriosis - pathology Endometrium Endometrium - pathology Engineering and Technology Female Ferric Compounds Gynecology Hyaluronic Acid Hyperthermia Inductively coupled plasma Injection Iron Iron oxides Laboratory animals Lesions Magnetic induction Magnetic resonance Magnetic resonance imaging Magnetic Resonance Imaging - methods Medical research Medicine and Health Sciences Methods Mice Morphology Nanoparticles Nanoparticles - chemistry NMR Nuclear magnetic resonance Obstetrics Optical emission spectroscopy Organs Physical Sciences Pigments Rats Rats, Sprague-Dawley Rodents Spectroscopy Transplantation Tumors Uterus |
| title | Hyaluronic acid-modified magnetic iron oxide nanoparticles for MR imaging of surgically induced endometriosis model in rats |
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