Chemical derivatives of a small molecule deubiquitinase inhibitor have antiviral activity against several RNA viruses

Most antiviral treatment options target the invading pathogen and unavoidably encounter loss of efficacy as the pathogen mutates to overcome replication restrictions. A good strategy for circumventing drug resistance, or for pathogens without treatment options, is to target host cell proteins that a...

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Veröffentlicht in:	PloS one 2014-04, Vol.9 (4), p.e94491
Hauptverfasser:	Gonzalez-Hernandez, Marta J, Pal, Anupama, Gyan, Kofi E, Charbonneau, Marie-Eve, Showalter, Hollis D, Donato, Nicholas J, O'Riordan, Mary, Wobus, Christiane E
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antiviral activity Antiviral Agents - chemistry Antiviral Agents - pharmacology Antiviral drugs Apoptosis B cells Biology and life sciences Bone marrow Cell Line Chemistry Cyanoacrylates Cytotoxicity Derivatives Drug resistance Encephalomyocarditis virus - drug effects Encephalomyocarditis virus - physiology Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Epidemics Health aspects Host-Pathogen Interactions Humans Immunology Infections Inhibitors Internal medicine La Crosse virus - drug effects La Crosse virus - physiology Macrophages Macrophages - drug effects Macrophages - virology Medical research Medicine and Health Sciences Mice Nitriles - chemistry Nitriles - pharmacology Norovirus - drug effects Norovirus - physiology Norwalk virus - drug effects Norwalk virus - physiology Pathogens Pharmaceutical sciences Physiological aspects Pretreatment Primary Cell Culture Proteins Pyridines - chemistry Pyridines - pharmacology Replication Research and Analysis Methods Ribonucleic acid RNA RNA viruses Sindbis Virus - drug effects Sindbis Virus - physiology Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology Solubility Structure-Activity Relationship Toxicity Ubiquitin-Specific Proteases - antagonists & inhibitors Ubiquitin-Specific Proteases - metabolism Viral infections Virus Replication - drug effects Viruses
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