Extracellular α-synuclein leads to microtubule destabilization via GSK-3β-dependent Tau phosphorylation in PC12 cells

α-Synuclein (ASN) plays an important role in pathogenesis of Parkinson's disease (PD) and other neurodegenerative disorders. Novel and most interesting data showed elevated tauopathy in PD and suggested relationship between ASN and Tau protein. However, the mechanism of ASN-evoked Tau protein m...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2014-04, Vol.9 (4), p.e94259-e94259
Hauptverfasser:	Gąssowska, Magdalena, Czapski, Grzegorz A, Pająk, Beata, Cieślik, Magdalena, Lenkiewicz, Anna M, Adamczyk, Agata
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - metabolism Alzheimer's disease Animals Apoptosis Biology and Life Sciences Cell death Cyclin-dependent kinase 5 Cytoskeleton - metabolism Cytotoxicity Destabilization Development and progression Gene expression Genetic aspects Glycogen Glycogen synthase kinase 3 Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Indoles - chemistry Inhibitors Kinases Maleimides - chemistry Medical research Medicine and Health Sciences Microtubules Microtubules - metabolism Movement disorders Nerve proteins Neurodegeneration Neurodegenerative diseases Parkinson's disease Pathogenesis PC12 Cells Pheochromocytoma cells Phosphorylation Physiological aspects Polymerization Proteins Rats Synuclein Tau protein tau Proteins - metabolism Time Factors Toxicity Tubulin Tubulin - metabolism Viability
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!