Impact of mutations in highly conserved amino acids of the HIV-1 Gag-p24 and Env-gp120 proteins on viral replication in different genetic backgrounds

It has been hypothesized that a single mutation at a highly conserved amino acid site (HCS) can be severely deleterious to HIV in most if not all isolate-specific genetic backgrounds. Consequently, potentially universal HIV-1 vaccines exclusively targeting highly conserved regions of the viral prote...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2014-04, Vol.9 (4), p.e94240-e94240
Hauptverfasser:	Liu, Yi, Rao, Ushnal, McClure, Jan, Konopa, Philip, Manocheewa, Siriphan, Kim, Moon, Chen, Lennie, Troyer, Ryan M, Tebit, Denis M, Holte, Sarah, Arts, Eric J, Mullins, James I
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Amino Acid Sequence Amino acids Bioinformatics Biology and life sciences Conservation Conserved Sequence Cytotoxicity Epidemiology Fitness Gag protein Gene mutations Genetic aspects Genetic Fitness Glycoprotein gp120 HIV HIV (Viruses) HIV Core Protein p24 - chemistry HIV Core Protein p24 - genetics HIV Envelope Protein gp120 - chemistry HIV Envelope Protein gp120 - genetics HIV-1 - genetics Human immunodeficiency virus Humans Hypotheses Immunology Infections Infectious diseases Medicine Medicine and Health Sciences Molecular Sequence Data Mutation Physiological aspects Proteins Proteomes Replication Reproductive fitness Sequence Alignment Vaccines Viral infections Viral proteins Virus Replication Viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!