Synergistic and antagonistic drug combinations depend on network topology

Drug combinations may exhibit synergistic or antagonistic effects. Rational design of synergistic drug combinations remains a challenge despite active experimental and computational efforts. Because drugs manifest their action via their targets, the effects of drug combinations should depend on the...

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Veröffentlicht in:	PloS one 2014-04, Vol.9 (4), p.e93960
Hauptverfasser:	Yin, Ning, Ma, Wenzhe, Pei, Jianfeng, Ouyang, Qi, Tang, Chao, Lai, Luhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biology Biology and Life Sciences Cell cycle Computer applications Drug Combinations Drug Design Drug development Drug Interactions Drug Synergism Drug therapy Drug therapy, Combination Drugs Enzymes Feedback loops Health aspects Life sciences Lung cancer Medicine and Health Sciences Metabolism Models, Theoretical Mutation Network topologies Networks Parameter sensitivity Positive feedback Topology Type 2 diabetes
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