CD8+ regulatory T cells, and not CD4+ T cells, dominate suppressive phenotype and function after in vitro live Mycobacterium bovis-BCG activation of human cells

Mycobacterium bovis bacillus Calmette-Guérin (M. bovis BCG), the only currently available vaccine against tuberculosis, has been reported to induce regulatory T cells in humans. The activity of regulatory T cells may not only dampen immunogenicity and protective efficacy of tuberculosis-vaccines, bu...

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Veröffentlicht in:	PloS one 2014-04, Vol.9 (4), p.e94192-e94192
Hauptverfasser:	Boer, Mardi C, van Meijgaarden, Krista E, Joosten, Simone A, Ottenhoff, Tom H M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Antigens, Surface - metabolism Bacillus Calmette-Guerin vaccine BCG BCG Vaccine - immunology Biology and Life Sciences CD25 antigen CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell activation Chemokines Comparative analysis Cytokines Genotype & phenotype Humans Immunity Immunogenicity Immunomodulation Immunophenotyping Immunoregulation Infectious diseases Ligands Lymphocyte Activation - immunology Lymphocytes Lymphocytes T Markers Medicine and Health Sciences Mycobacterium bovis Mycobacterium bovis - immunology Mycobacterium tuberculosis Phenotype Research and Analysis Methods T cell receptors T-Lymphocyte Subsets - immunology T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Tuberculosis Vaccination Vaccines γ-Interferon
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