Leukocyte attraction by CCL20 and its receptor CCR6 in humans and mice with pneumococcal meningitis

We previously identified CCL20 as an early chemokine in the cerebrospinal fluid (CSF) of patients with pneumococcal meningitis but its functional relevance was unknown. Here we studied the role of CCL20 and its receptor CCR6 in pneumococcal meningitis. In a prospective nationwide study, CCL20 levels...

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Veröffentlicht in:	PloS one 2014-04, Vol.9 (4), p.e93057-e93057
Hauptverfasser:	Klein, Matthias, Brouwer, Matthijs C, Angele, Barbara, Geldhoff, Madelijn, Marquez, Gabriel, Varona, Rosa, Häcker, Georg, Schmetzer, Helga, Häcker, Hans, Hammerschmidt, Sven, van der Ende, Arie, Pfister, Hans-Walter, van de Beek, Diederik, Koedel, Uwe
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Antibodies Antibodies, Monoclonal - pharmacology Bacteria Bacterial infections Biology and Life Sciences Blotting, Western Brain Brain - immunology Brain - metabolism Brain - microbiology Case-Control Studies CCL20 protein CCR6 protein Cells, Cultured Cerebrospinal fluid Chemokine CCL20 - antagonists & inhibitors Chemokine CCL20 - immunology Chemokine CCL20 - metabolism Chemokines Chemotaxis, Leukocyte - immunology Cytokines Dendritic cells Enzyme-Linked Immunosorbent Assay Female Flow Cytometry Helicobacter pylori Humans Immune system Immunoenzyme Techniques Inflammatory bowel disease Leukocytes Leukocytes (granulocytic) Ligands Male Medicine and Health Sciences Meningitis Meningitis, Pneumococcal - cerebrospinal fluid Meningitis, Pneumococcal - immunology Meningitis, Pneumococcal - metabolism Meningitis, Pneumococcal - microbiology Mice Mice, Inbred C57BL Mice, Knockout Neurology Neutrophils Patients Pleocytosis Prognosis Prospective Studies Receptors, CCR6 - physiology Recruitment Streptococcus infections Streptococcus pneumoniae Survival Rate Tumor Cells, Cultured
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