Targeted disruption of LDLR causes hypercholesterolemia and atherosclerosis in Yucatan miniature pigs

Recent progress in engineering the genomes of large animals has spurred increased interest in developing better animal models for diseases where current options are inadequate. Here, we report the creation of Yucatan miniature pigs with targeted disruptions of the low-density lipoprotein receptor (L...

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Veröffentlicht in:	PloS one 2014-04, Vol.9 (4), p.e93457-e93457
Hauptverfasser:	Davis, Bryan T, Wang, Xiao-Jun, Rohret, Judy A, Struzynski, Jason T, Merricks, Elizabeth P, Bellinger, Dwight A, Rohret, Frank A, Nichols, Timothy C, Rogers, Christopher S
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal models Animals Animals, Genetically Modified Aorta Aorta - metabolism Aorta - pathology Arteries Arteriosclerosis Atherosclerosis Atherosclerosis - genetics Atherosclerosis - metabolism Atherosclerosis - pathology Biology and Life Sciences Breeding Cardiovascular diseases Care and treatment Cholesterol Complications Coronary artery Coronary Vessels - metabolism Coronary Vessels - pathology Cystic fibrosis Diagnosis Diet Disease Models, Animal Female Gene Order Gene Targeting Genetic aspects Genetic Loci Genetics Genomes Genotype Heterozygotes Hogs Hypercholesterolemia Hypercholesterolemia - genetics Hypercholesterolemia - metabolism Lesions Lipid Metabolism Lipids - blood Livestock Livestock breeding Low density lipoprotein Low density lipoprotein receptors Low density lipoproteins Low fat Male Medicine and Health Sciences Mutation Nuclear transfer Physiological aspects Receptor density Receptors, LDL - genetics Receptors, LDL - metabolism Research and Analysis Methods Risk factors Rodents Somatic cell nuclear transfer Swine Swine, Miniature Time Factors Viruses
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