Dietary supplementation with Lactobacilli improves emergency granulopoiesis in protein-malnourished mice and enhances respiratory innate immune response
This work studied the effect of protein malnutrition on the hemato-immune response to the respiratory challenge with Streptococcus pneumoniae and evaluated whether the dietary recovery with a probiotic strain has a beneficial effect in that response. Three important conclusions can be inferred from...
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| creator | Herrera, Matias Salva, Susana Villena, Julio Barbieri, Natalia Marranzino, Gabriela Alvarez, Susana |
| description | This work studied the effect of protein malnutrition on the hemato-immune response to the respiratory challenge with Streptococcus pneumoniae and evaluated whether the dietary recovery with a probiotic strain has a beneficial effect in that response. Three important conclusions can be inferred from the results presented in this work: a) protein-malnutrition significantly impairs the emergency myelopoiesis induced by the generation of the innate immune response against pneumococcal infection; b) repletion of malnourished mice with treatments including nasally or orally administered Lactobacillus rhamnosus CRL1505 are able to significantly accelerate the recovery of granulopoiesis and improve innate immunity and; c) the immunological mechanisms involved in the protective effect of immunobiotics vary according to the route of administration. The study demonstrated that dietary recovery of malnourished mice with oral or nasal administration of L. rhamnosus CRL1505 improves emergency granulopoiesis and that CXCR4/CXCR12 signaling would be involved in this effect. Then, the results summarized here are a starting point for future research and open up broad prospects for future applications of probiotics in the recovery of immunocompromised malnourished hosts. |
| doi_str_mv | 10.1371/journal.pone.0090227 |
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Three important conclusions can be inferred from the results presented in this work: a) protein-malnutrition significantly impairs the emergency myelopoiesis induced by the generation of the innate immune response against pneumococcal infection; b) repletion of malnourished mice with treatments including nasally or orally administered Lactobacillus rhamnosus CRL1505 are able to significantly accelerate the recovery of granulopoiesis and improve innate immunity and; c) the immunological mechanisms involved in the protective effect of immunobiotics vary according to the route of administration. The study demonstrated that dietary recovery of malnourished mice with oral or nasal administration of L. rhamnosus CRL1505 improves emergency granulopoiesis and that CXCR4/CXCR12 signaling would be involved in this effect. Then, the results summarized here are a starting point for future research and open up broad prospects for future applications of probiotics in the recovery of immunocompromised malnourished hosts.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0090227</identifier><identifier>PMID: 24691464</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; B cells ; Bacterial pneumonia ; Biology and Life Sciences ; Bone marrow ; Bone Marrow - pathology ; Bronchoalveolar Lavage Fluid ; Care and treatment ; Complications and side effects ; CXCR4 protein ; Cytokines - blood ; Diagnosis ; Diet ; Dietary Supplements ; Emergency response ; Granulocytes ; Granulopoiesis ; Immune response ; Immune system ; Immunity ; Immunity, Innate - immunology ; Immunology ; Infectious diseases ; Innate immunity ; Intercellular Signaling Peptides and Proteins - metabolism ; Intranasal administration ; Laboratories ; Lactobacilli ; Lactobacillus casei ; Lactobacillus rhamnosus ; Lactobacillus rhamnosus - immunology ; Leukopoiesis - immunology ; Lung - immunology ; Malnutrition ; Medicine and Health Sciences ; Mice ; Myeloid Cells - pathology ; Myelopoiesis ; Oral administration ; Patient outcomes ; Physiological aspects ; Pneumococcal Infections - blood ; Pneumococcal Infections - immunology ; Pneumococcal Infections - microbiology ; Pneumonia ; Probiotics ; Protein-Energy Malnutrition - blood ; Protein-Energy Malnutrition - immunology ; Protein-Energy Malnutrition - microbiology ; Proteins ; Recovery ; Research and Analysis Methods ; Respiration ; Rodents ; Signaling ; Stem cells ; Streptococcus infections ; Streptococcus pneumoniae</subject><ispartof>PloS one, 2014-04, Vol.9 (4), p.e90227-e90227</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Herrera et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Three important conclusions can be inferred from the results presented in this work: a) protein-malnutrition significantly impairs the emergency myelopoiesis induced by the generation of the innate immune response against pneumococcal infection; b) repletion of malnourished mice with treatments including nasally or orally administered Lactobacillus rhamnosus CRL1505 are able to significantly accelerate the recovery of granulopoiesis and improve innate immunity and; c) the immunological mechanisms involved in the protective effect of immunobiotics vary according to the route of administration. The study demonstrated that dietary recovery of malnourished mice with oral or nasal administration of L. rhamnosus CRL1505 improves emergency granulopoiesis and that CXCR4/CXCR12 signaling would be involved in this effect. Then, the results summarized here are a starting point for future research and open up broad prospects for future applications of probiotics in the recovery of immunocompromised malnourished hosts.</description><subject>Animals</subject><subject>B cells</subject><subject>Bacterial pneumonia</subject><subject>Biology and Life Sciences</subject><subject>Bone marrow</subject><subject>Bone Marrow - pathology</subject><subject>Bronchoalveolar Lavage Fluid</subject><subject>Care and treatment</subject><subject>Complications and side effects</subject><subject>CXCR4 protein</subject><subject>Cytokines - blood</subject><subject>Diagnosis</subject><subject>Diet</subject><subject>Dietary Supplements</subject><subject>Emergency response</subject><subject>Granulocytes</subject><subject>Granulopoiesis</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunity</subject><subject>Immunity, Innate - immunology</subject><subject>Immunology</subject><subject>Infectious diseases</subject><subject>Innate immunity</subject><subject>Intercellular Signaling Peptides and Proteins - 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microbiology</subject><subject>Proteins</subject><subject>Recovery</subject><subject>Research and Analysis Methods</subject><subject>Respiration</subject><subject>Rodents</subject><subject>Signaling</subject><subject>Stem cells</subject><subject>Streptococcus infections</subject><subject>Streptococcus pneumoniae</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7rr6D0QLgujFjE2aptMbYVm_BgYW_LoNp-lpmyFNukm6uv_En2vmY5cZ2QvpRUryvO9J3uQkyXOSzUlekndrOzkDej5ag_MsqzJKywfJKalyOuM0yx8e_J8kT7xfZ1mRLzh_nJxQxivCODtN_nxQGMDdpH4aR40DmgBBWZP-UqFPVyCDrUEqrVWqhtHZa_RppFyHRt6knQMzaTtahV75VJk0IgGVmQ2gTdyg8j026aAkpmCaFE0PRkYLh35UDoKNlZUxEDDaD5PB7Yo1Hp8mj1rQHp_tx7Pkx6eP3y--zFaXn5cX56uZ5BUNM8pI0ciq5nVNKS95Seq64QwaWDAsakAuSUMRCyIZy2WFZQlRg7QumGyLJj9LXu58R2292IfqBSkIWbBFTheRWO6IxsJajE4NMS9hQYnthHWdABeU1ChymmUoq1a2NWENVLVskLGS06ogkJUser3fV5vqARsZ43agj0yPV4zqRWevRV6VlHASDd7sDZy9mtAHMSgvUWswaKftvmnBM0qKiL76B73_dHuqg3gAZVob68qNqTjPy6JYUJZXkZrfQ8WvwXi58QW2Ks4fCd4eCSIT8HfoYPJeLL99_X_28ucx-_qA7RF06L3V0-bN-mOQ7UDprPcO27uQSSY2DXSbhtg0kNg3UJS9OLygO9Ftx-R_AWO9G1A</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Herrera, Matias</creator><creator>Salva, Susana</creator><creator>Villena, Julio</creator><creator>Barbieri, Natalia</creator><creator>Marranzino, Gabriela</creator><creator>Alvarez, Susana</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140401</creationdate><title>Dietary supplementation with Lactobacilli improves emergency granulopoiesis in protein-malnourished mice and enhances respiratory innate immune response</title><author>Herrera, Matias ; Salva, Susana ; Villena, Julio ; Barbieri, Natalia ; Marranzino, Gabriela ; Alvarez, Susana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-2415dc9b6bb2267671bbd64ada84e5bae6c1d2ee51c443c9e77a241e2b54cf5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>B cells</topic><topic>Bacterial pneumonia</topic><topic>Biology and Life Sciences</topic><topic>Bone marrow</topic><topic>Bone Marrow - pathology</topic><topic>Bronchoalveolar Lavage Fluid</topic><topic>Care and treatment</topic><topic>Complications and side effects</topic><topic>CXCR4 protein</topic><topic>Cytokines - blood</topic><topic>Diagnosis</topic><topic>Diet</topic><topic>Dietary Supplements</topic><topic>Emergency response</topic><topic>Granulocytes</topic><topic>Granulopoiesis</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunity</topic><topic>Immunity, Innate - immunology</topic><topic>Immunology</topic><topic>Infectious diseases</topic><topic>Innate immunity</topic><topic>Intercellular Signaling Peptides and Proteins - metabolism</topic><topic>Intranasal administration</topic><topic>Laboratories</topic><topic>Lactobacilli</topic><topic>Lactobacillus casei</topic><topic>Lactobacillus rhamnosus</topic><topic>Lactobacillus rhamnosus - immunology</topic><topic>Leukopoiesis - immunology</topic><topic>Lung - immunology</topic><topic>Malnutrition</topic><topic>Medicine and Health Sciences</topic><topic>Mice</topic><topic>Myeloid Cells - 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Three important conclusions can be inferred from the results presented in this work: a) protein-malnutrition significantly impairs the emergency myelopoiesis induced by the generation of the innate immune response against pneumococcal infection; b) repletion of malnourished mice with treatments including nasally or orally administered Lactobacillus rhamnosus CRL1505 are able to significantly accelerate the recovery of granulopoiesis and improve innate immunity and; c) the immunological mechanisms involved in the protective effect of immunobiotics vary according to the route of administration. The study demonstrated that dietary recovery of malnourished mice with oral or nasal administration of L. rhamnosus CRL1505 improves emergency granulopoiesis and that CXCR4/CXCR12 signaling would be involved in this effect. Then, the results summarized here are a starting point for future research and open up broad prospects for future applications of probiotics in the recovery of immunocompromised malnourished hosts.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24691464</pmid><doi>10.1371/journal.pone.0090227</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2014-04, Vol.9 (4), p.e90227-e90227 |
| issn | 1932-6203 1932-6203 |
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| recordid | cdi_plos_journals_1511848328 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animals B cells Bacterial pneumonia Biology and Life Sciences Bone marrow Bone Marrow - pathology Bronchoalveolar Lavage Fluid Care and treatment Complications and side effects CXCR4 protein Cytokines - blood Diagnosis Diet Dietary Supplements Emergency response Granulocytes Granulopoiesis Immune response Immune system Immunity Immunity, Innate - immunology Immunology Infectious diseases Innate immunity Intercellular Signaling Peptides and Proteins - metabolism Intranasal administration Laboratories Lactobacilli Lactobacillus casei Lactobacillus rhamnosus Lactobacillus rhamnosus - immunology Leukopoiesis - immunology Lung - immunology Malnutrition Medicine and Health Sciences Mice Myeloid Cells - pathology Myelopoiesis Oral administration Patient outcomes Physiological aspects Pneumococcal Infections - blood Pneumococcal Infections - immunology Pneumococcal Infections - microbiology Pneumonia Probiotics Protein-Energy Malnutrition - blood Protein-Energy Malnutrition - immunology Protein-Energy Malnutrition - microbiology Proteins Recovery Research and Analysis Methods Respiration Rodents Signaling Stem cells Streptococcus infections Streptococcus pneumoniae |
| title | Dietary supplementation with Lactobacilli improves emergency granulopoiesis in protein-malnourished mice and enhances respiratory innate immune response |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T20%3A59%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dietary%20supplementation%20with%20Lactobacilli%20improves%20emergency%20granulopoiesis%20in%20protein-malnourished%20mice%20and%20enhances%20respiratory%20innate%20immune%20response&rft.jtitle=PloS%20one&rft.au=Herrera,%20Matias&rft.date=2014-04-01&rft.volume=9&rft.issue=4&rft.spage=e90227&rft.epage=e90227&rft.pages=e90227-e90227&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0090227&rft_dat=%3Cgale_plos_%3EA375582439%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1511848328&rft_id=info:pmid/24691464&rft_galeid=A375582439&rft_doaj_id=oai_doaj_org_article_3200ec9fcfb14da9bcde44762951a074&rfr_iscdi=true |