Immunization with a peptide containing MHC class I and II epitopes derived from the tumor antigen SIM2 induces an effective CD4 and CD8 T-cell response

Here, we sought to determine whether peptide vaccines designed harbor both class I as well as class II restricted antigenic motifs could concurrently induce CD4 and CD8 T cell activation against autologous tumor antigens. Based on our prior genome-wide interrogation of human prostate cancer tissues...

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Veröffentlicht in:	PloS one 2014-04, Vol.9 (4), p.e93231-e93231
Hauptverfasser:	Kissick, Haydn T, Sanda, Martin G, Dunn, Laura K, Arredouani, Mohamed S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animal tissues Animals Antigen (tumor-associated) Antigen presentation Antigen Presentation - immunology Antigens Antigens, Neoplasm - chemistry Antigens, Neoplasm - immunology Basic Helix-Loop-Helix Transcription Factors - chemistry Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - immunology Biology and Life Sciences Breast cancer Cancer Cancer vaccines Cancer Vaccines - immunology CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell activation Cell Line Clinical trials Cytokines - biosynthesis Drug therapy Epitopes Epitopes, T-Lymphocyte - chemistry Epitopes, T-Lymphocyte - immunology Gene Expression Gene Expression Profiling Genetic aspects Genomes Health aspects Histocompatibility antigen HLA Histocompatibility Antigens Class I - immunology Histocompatibility Antigens Class II - immunology HLA-A2 Antigen - immunology Human papillomavirus Humans Immunization Immunotherapy Interferon Interleukin 2 Interrogation Lymphocytes Lymphocytes T Major histocompatibility complex Male Medicine and Health Sciences Melanoma Mesothelioma Mice Mice, Transgenic Neoplasms - genetics Neoplasms - immunology Neoplasms - metabolism Neoplasms - therapy Peptides Peptides - chemistry Peptides - immunology Physiological aspects Prostate cancer Proteins Research and Analysis Methods Spleen - cytology Spleen - immunology Surgery T cells Transgenic mice Tumor cells Tumors Urology Vaccines γ-Interferon
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