Drosophila Mcm10 is required for DNA replication and differentiation in the compound eye

Mini chromosome maintenance 10 (Mcm10) is an essential protein, which is conserved from S. cerevisiae to Drosophila and human, and is required for the initiation of DNA replication. Knockdown of Drosophila Mcm10 (dMcm10) by RNA interference in eye imaginal discs induces abnormal eye morphology (roug...

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Veröffentlicht in:	PloS one 2014-03, Vol.9 (3), p.e93450-e93450
Hauptverfasser:	Vo, Nicole, Taga, Ayano, Inaba, Yasuhiro, Yoshida, Hideki, Cotterill, Sue, Yamaguchi, Masamitsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified - genetics Animals, Genetically Modified - metabolism Apoptosis Apoptosis - genetics Biology Biology and life sciences Biomedical research Cell cycle Cell differentiation Cell Differentiation - genetics Cell division Cell Division - genetics Chromosomes Compound eye Deoxyribonucleic acid Differentiation (biology) DNA DNA biosynthesis DNA replication DNA Replication - genetics Drosophila Drosophila - genetics Drosophila melanogaster Drosophila Proteins - genetics Eye Eye - metabolism Genomes Imaginal discs Imaginal Discs - metabolism Insects Minichromosome Maintenance Proteins - genetics Neurogenesis - genetics Ommatidia Phenotype Photoreceptor Cells, Invertebrate - metabolism Proteins Replication Replication initiation Research and Analysis Methods Ribonucleic acid RNA RNA-mediated interference S phase S Phase - genetics Saccharomyces cerevisiae Studies Yeast
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