Radiosynthesis and biological evaluation of N-[18F]labeled glutamic acid as a tumor metabolic imaging tracer

We have previously reported that N-(2-[18F]fluoropropionyl)-L-methionine ([18F]FPMET) selectively accumulates in tumors. However, due to the poor pharmacokinetics of [18F]FPMET in vivo, the potential clinical translation of this observation is hampered. In this study, we rationally designed and synt...

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Veröffentlicht in:	PloS one 2014-03, Vol.9 (3), p.e93262
Hauptverfasser:	Hu, Kongzhen, Du, Kan, Tang, Ganghua, Yao, Shaobo, Wang, Hongliang, Liang, Xiang, Yao, Baoguo, Huang, Tingting, Zang, Linquan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Amino acids Animal models Animal tissues Animals Automation Brain cancer Cell Line, Tumor Diagnostic Imaging - methods Glucose Glutamate Glutamic acid Glutamic Acid - chemistry Imaging Isotope Labeling - methods Laboratory animals Lung cancer Medical imaging Medicine and Health Sciences Metabolism Metabolites Methionine Methionine - chemistry Mice Nuclear medicine Pharmacokinetics Pharmacology Pharmacy Positron emission Positron emission tomography Positron-Emission Tomography - methods Prostate Radiochemistry Radiopharmaceuticals - chemistry Sensors Solvents Studies Synthesis Tissue Distribution - physiology Tissues Tomography Tracers (Biology) Tumors Urine
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