Activation of nucleotide oligomerization domain 2 (NOD2) by human cytomegalovirus initiates innate immune responses and restricts virus replication

Nucleotide-binding oligomerization domain 2 (NOD2) is an important innate immune sensor of bacterial pathogens. Its induction results in activation of the classic NF-κB pathway and alternative pathways including type I IFN and autophagy. Although the importance of NOD2 in recognizing RNA viruses has...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2014-03, Vol.9 (3), p.e92704-e92704
Hauptverfasser:	Kapoor, Arun, Forman, Michael, Arav-Boger, Ravit
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Autophagy Bacteria Biological response modifiers Biology and life sciences Brain tumors Cell Line Coding Colitis Crohn's Disease Crohns disease Cytokines Cytokines - metabolism Cytomegalovirus Cytomegalovirus - physiology Cytomegalovirus - radiation effects Cytomegalovirus infections Cytomegalovirus Infections - immunology Deoxyribonucleic acid DNA DNA viruses Drug dosages Fibroblasts Fibroblasts - metabolism Fibroblasts - radiation effects Fibroblasts - virology Gene Knockdown Techniques Genes Glioma cells Glycoprotein B Glycoproteins Gram-positive bacteria Health aspects Herpesviridae - physiology Herpesviridae - radiation effects Humans Immune response Immune system Immunity, Innate - radiation effects Infection Infections Inflammation Inflammation Mediators - metabolism Inflammatory bowel diseases Innate immunity Interferon Interferons - metabolism Interleukin 8 Kinetics Laboratories Localization Male Medical research Medicine and Health Sciences Mutant Proteins - metabolism Mutation NF-kappa B - metabolism NF-κB protein NOD2 protein Nod2 Signaling Adaptor Protein - genetics Nod2 Signaling Adaptor Protein - metabolism Oligomerization Oligomers Patients Pediatrics Phagocytosis Plasmids Proteins Replication Ribonucleic acid RNA RNA viruses RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Transplants & implants Ultraviolet Rays Viral Envelope Proteins - metabolism Virions Virus Inactivation - radiation effects Virus replication Virus Replication - physiology Virus Replication - radiation effects Viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!