Joint effects of colorectal cancer susceptibility loci, circulating 25-hydroxyvitamin D and risk of colorectal cancer
Genome wide association studies (GWAS) have identified several SNPs associated with colorectal cancer (CRC) susceptibility. Vitamin D is also inversely associated with CRC risk. We examined main and joint effects of previously GWAS identified genetic markers of CRC and plasma 25-hydroxyvitamin D (25...
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| Veröffentlicht in: | PloS one 2014-03, Vol.9 (3), p.e92212-e92212 |
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| creator | Hiraki, Linda T Joshi, Amit D Ng, Kimmie Fuchs, Charles S Ma, Jing Hazra, Aditi Peters, Ulrike Karlson, Elizabeth W Giovannucci, Edward Kraft, Peter Chan, Andrew T |
| description | Genome wide association studies (GWAS) have identified several SNPs associated with colorectal cancer (CRC) susceptibility. Vitamin D is also inversely associated with CRC risk.
We examined main and joint effects of previously GWAS identified genetic markers of CRC and plasma 25-hydroxyvitamin D (25(OH)D) on CRC risk in three prospective cohorts: the Nurses' Health Study (NHS), the Health Professionals Follow-up Study (HPFS), and the Physicians' Health Study (PHS). We included 1895 CRC cases and 2806 controls with genomic DNA. We calculated odds ratios and 95% confidence intervals for CRC associated with additive genetic risk scores (GRSs) comprised of all CRC SNPs and subsets of these SNPs based on proximity to regions of increased vitamin D receptor binding to vitamin D response elements (VDREs), based on published ChiP-seq data. Among a subset of subjects with additional prediagnostic 25(OH)D we tested multiplicative interactions between plasma 25(OH)D and GRS's. We used fixed effects models to meta-analyze the three cohorts.
The per allele multivariate OR was 1.12 (95% CI, 1.06-1.19) for GRS-proximalVDRE; and 1.10 (95% CI, 1.06-1.14) for GRS-nonproxVDRE. The lowest quartile of plasma 25(OH)D compared with the highest, had a multivariate OR of 0.63 (95% CI, 0.48-0.82) for CRC. We did not observe any significant interactions between any GRSs and plasma 25(OH)D.
We did not observe evidence for the modification of genetic susceptibility for CRC according to vitamin D status, or evidence that the effect of common CRC risk alleles differed according to their proximity to putative VDR binding sites. |
| doi_str_mv | 10.1371/journal.pone.0092212 |
| format | Article |
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We examined main and joint effects of previously GWAS identified genetic markers of CRC and plasma 25-hydroxyvitamin D (25(OH)D) on CRC risk in three prospective cohorts: the Nurses' Health Study (NHS), the Health Professionals Follow-up Study (HPFS), and the Physicians' Health Study (PHS). We included 1895 CRC cases and 2806 controls with genomic DNA. We calculated odds ratios and 95% confidence intervals for CRC associated with additive genetic risk scores (GRSs) comprised of all CRC SNPs and subsets of these SNPs based on proximity to regions of increased vitamin D receptor binding to vitamin D response elements (VDREs), based on published ChiP-seq data. Among a subset of subjects with additional prediagnostic 25(OH)D we tested multiplicative interactions between plasma 25(OH)D and GRS's. We used fixed effects models to meta-analyze the three cohorts.
The per allele multivariate OR was 1.12 (95% CI, 1.06-1.19) for GRS-proximalVDRE; and 1.10 (95% CI, 1.06-1.14) for GRS-nonproxVDRE. The lowest quartile of plasma 25(OH)D compared with the highest, had a multivariate OR of 0.63 (95% CI, 0.48-0.82) for CRC. We did not observe any significant interactions between any GRSs and plasma 25(OH)D.
We did not observe evidence for the modification of genetic susceptibility for CRC according to vitamin D status, or evidence that the effect of common CRC risk alleles differed according to their proximity to putative VDR binding sites.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0092212</identifier><identifier>PMID: 24670869</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>25-Hydroxyvitamin D ; Adult ; Aged ; Aged, 80 and over ; Alleles ; Binding sites ; Biology and Life Sciences ; Cancer ; Cancer research ; Cardiovascular disease ; Case-Control Studies ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - blood ; Colorectal Neoplasms - genetics ; Confidence intervals ; Deoxyribonucleic acid ; Disease susceptibility ; DNA ; Female ; Genetic aspects ; Genetic Loci ; Genetic markers ; Genetic Predisposition to Disease ; Genome-wide association studies ; Genomes ; Health aspects ; Health risk assessment ; Health risks ; Humans ; Male ; Medical personnel ; Medicine and Health Sciences ; Middle Aged ; Physicians ; Regulatory sequences ; Risk ; Risk Factors ; Single-nucleotide polymorphism ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D receptors ; Womens health</subject><ispartof>PloS one, 2014-03, Vol.9 (3), p.e92212-e92212</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Hiraki et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Hiraki et al 2014 Hiraki et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-2869b1a008d712eab0ada6582ceed77b487786da22c65d55c18850e2dbcb6a293</citedby><cites>FETCH-LOGICAL-c692t-2869b1a008d712eab0ada6582ceed77b487786da22c65d55c18850e2dbcb6a293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966783/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966783/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23864,27922,27923,53789,53791,79370,79371</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24670869$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Miao, Xiaoping</contributor><creatorcontrib>Hiraki, Linda T</creatorcontrib><creatorcontrib>Joshi, Amit D</creatorcontrib><creatorcontrib>Ng, Kimmie</creatorcontrib><creatorcontrib>Fuchs, Charles S</creatorcontrib><creatorcontrib>Ma, Jing</creatorcontrib><creatorcontrib>Hazra, Aditi</creatorcontrib><creatorcontrib>Peters, Ulrike</creatorcontrib><creatorcontrib>Karlson, Elizabeth W</creatorcontrib><creatorcontrib>Giovannucci, Edward</creatorcontrib><creatorcontrib>Kraft, Peter</creatorcontrib><creatorcontrib>Chan, Andrew T</creatorcontrib><title>Joint effects of colorectal cancer susceptibility loci, circulating 25-hydroxyvitamin D and risk of colorectal cancer</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Genome wide association studies (GWAS) have identified several SNPs associated with colorectal cancer (CRC) susceptibility. Vitamin D is also inversely associated with CRC risk.
We examined main and joint effects of previously GWAS identified genetic markers of CRC and plasma 25-hydroxyvitamin D (25(OH)D) on CRC risk in three prospective cohorts: the Nurses' Health Study (NHS), the Health Professionals Follow-up Study (HPFS), and the Physicians' Health Study (PHS). We included 1895 CRC cases and 2806 controls with genomic DNA. We calculated odds ratios and 95% confidence intervals for CRC associated with additive genetic risk scores (GRSs) comprised of all CRC SNPs and subsets of these SNPs based on proximity to regions of increased vitamin D receptor binding to vitamin D response elements (VDREs), based on published ChiP-seq data. Among a subset of subjects with additional prediagnostic 25(OH)D we tested multiplicative interactions between plasma 25(OH)D and GRS's. We used fixed effects models to meta-analyze the three cohorts.
The per allele multivariate OR was 1.12 (95% CI, 1.06-1.19) for GRS-proximalVDRE; and 1.10 (95% CI, 1.06-1.14) for GRS-nonproxVDRE. The lowest quartile of plasma 25(OH)D compared with the highest, had a multivariate OR of 0.63 (95% CI, 0.48-0.82) for CRC. We did not observe any significant interactions between any GRSs and plasma 25(OH)D.
We did not observe evidence for the modification of genetic susceptibility for CRC according to vitamin D status, or evidence that the effect of common CRC risk alleles differed according to their proximity to putative VDR binding sites.</description><subject>25-Hydroxyvitamin D</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alleles</subject><subject>Binding sites</subject><subject>Biology and Life Sciences</subject><subject>Cancer</subject><subject>Cancer research</subject><subject>Cardiovascular disease</subject><subject>Case-Control Studies</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - blood</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Confidence intervals</subject><subject>Deoxyribonucleic acid</subject><subject>Disease susceptibility</subject><subject>DNA</subject><subject>Female</subject><subject>Genetic aspects</subject><subject>Genetic Loci</subject><subject>Genetic markers</subject><subject>Genetic Predisposition to Disease</subject><subject>Genome-wide association studies</subject><subject>Genomes</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Humans</subject><subject>Male</subject><subject>Medical personnel</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Physicians</subject><subject>Regulatory sequences</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Single-nucleotide polymorphism</subject><subject>Vitamin D</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Vitamin D receptors</subject><subject>Womens health</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9luEzEUhkcIREvhDRCMVAmBRIKX8TI3SFXZgipVYru1vE3i4oyD7amat8dpplWCcoF84e07v31--1TVcwimEDP47ioMsZd-ugq9nQLQIgTRg-oYthhNKAL44c74qHqS0hUABHNKH1dHqKEMcNoeV8PX4Ppc266zOqc6dLUOPsQykb7Wstc21mlI2q6yU867vK590O5trV3Ug5fZ9fMakclibWK4WV-7LJeurz_Usjd1dOn3Qcmn1aNO-mSfjf1J9fPTxx_nXyYXl59n52cXE01blCeoXFFBCQA3DCIrFZBGUsKRttYwphrOGKdGIqQpMYRoyDkBFhmlFZWoxSfVy63uyockRseSgAQCAgDGpBCzLWGCvBKr6JYyrkWQTtwuhDgXMmanvRWYt5goTTsFugZ0nYTFNcVgBxVojFJF6_142qCW1mjb5yj9nuj-Tu8WYh6uBW4pZRwXgdejQAx_BpuyWLpivfeyt2G4vTfEbcP5JrPTf9DD2Y3UXJYEXN-Fcq7eiIqzhnHWMECaQk0PUKUZu3S6fK_OlfW9gDd7AYXJ9ibP5ZCSmH3_9v_s5a999tUOu7DS50UKfsgu9GkfbLagjiGlaLt7kyEQm-q4c0NsqkOM1VHCXuw-0H3QXTngvwpiC_E</recordid><startdate>20140326</startdate><enddate>20140326</enddate><creator>Hiraki, Linda T</creator><creator>Joshi, Amit D</creator><creator>Ng, Kimmie</creator><creator>Fuchs, Charles S</creator><creator>Ma, Jing</creator><creator>Hazra, Aditi</creator><creator>Peters, Ulrike</creator><creator>Karlson, Elizabeth W</creator><creator>Giovannucci, Edward</creator><creator>Kraft, Peter</creator><creator>Chan, Andrew T</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140326</creationdate><title>Joint effects of colorectal cancer susceptibility loci, circulating 25-hydroxyvitamin D and risk of colorectal cancer</title><author>Hiraki, Linda T ; Joshi, Amit D ; Ng, Kimmie ; Fuchs, Charles S ; Ma, Jing ; Hazra, Aditi ; Peters, Ulrike ; Karlson, Elizabeth W ; Giovannucci, Edward ; Kraft, Peter ; Chan, Andrew T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-2869b1a008d712eab0ada6582ceed77b487786da22c65d55c18850e2dbcb6a293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>25-Hydroxyvitamin D</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alleles</topic><topic>Binding sites</topic><topic>Biology and Life Sciences</topic><topic>Cancer</topic><topic>Cancer research</topic><topic>Cardiovascular disease</topic><topic>Case-Control Studies</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - blood</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Confidence intervals</topic><topic>Deoxyribonucleic acid</topic><topic>Disease susceptibility</topic><topic>DNA</topic><topic>Female</topic><topic>Genetic aspects</topic><topic>Genetic Loci</topic><topic>Genetic markers</topic><topic>Genetic Predisposition to Disease</topic><topic>Genome-wide association studies</topic><topic>Genomes</topic><topic>Health aspects</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Humans</topic><topic>Male</topic><topic>Medical personnel</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Physicians</topic><topic>Regulatory sequences</topic><topic>Risk</topic><topic>Risk Factors</topic><topic>Single-nucleotide polymorphism</topic><topic>Vitamin D</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>Vitamin D receptors</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hiraki, Linda T</creatorcontrib><creatorcontrib>Joshi, Amit D</creatorcontrib><creatorcontrib>Ng, Kimmie</creatorcontrib><creatorcontrib>Fuchs, Charles S</creatorcontrib><creatorcontrib>Ma, Jing</creatorcontrib><creatorcontrib>Hazra, Aditi</creatorcontrib><creatorcontrib>Peters, Ulrike</creatorcontrib><creatorcontrib>Karlson, Elizabeth W</creatorcontrib><creatorcontrib>Giovannucci, Edward</creatorcontrib><creatorcontrib>Kraft, Peter</creatorcontrib><creatorcontrib>Chan, Andrew T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hiraki, Linda T</au><au>Joshi, Amit D</au><au>Ng, Kimmie</au><au>Fuchs, Charles S</au><au>Ma, Jing</au><au>Hazra, Aditi</au><au>Peters, Ulrike</au><au>Karlson, Elizabeth W</au><au>Giovannucci, Edward</au><au>Kraft, Peter</au><au>Chan, Andrew T</au><au>Miao, Xiaoping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Joint effects of colorectal cancer susceptibility loci, circulating 25-hydroxyvitamin D and risk of colorectal cancer</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-03-26</date><risdate>2014</risdate><volume>9</volume><issue>3</issue><spage>e92212</spage><epage>e92212</epage><pages>e92212-e92212</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Genome wide association studies (GWAS) have identified several SNPs associated with colorectal cancer (CRC) susceptibility. Vitamin D is also inversely associated with CRC risk.
We examined main and joint effects of previously GWAS identified genetic markers of CRC and plasma 25-hydroxyvitamin D (25(OH)D) on CRC risk in three prospective cohorts: the Nurses' Health Study (NHS), the Health Professionals Follow-up Study (HPFS), and the Physicians' Health Study (PHS). We included 1895 CRC cases and 2806 controls with genomic DNA. We calculated odds ratios and 95% confidence intervals for CRC associated with additive genetic risk scores (GRSs) comprised of all CRC SNPs and subsets of these SNPs based on proximity to regions of increased vitamin D receptor binding to vitamin D response elements (VDREs), based on published ChiP-seq data. Among a subset of subjects with additional prediagnostic 25(OH)D we tested multiplicative interactions between plasma 25(OH)D and GRS's. We used fixed effects models to meta-analyze the three cohorts.
The per allele multivariate OR was 1.12 (95% CI, 1.06-1.19) for GRS-proximalVDRE; and 1.10 (95% CI, 1.06-1.14) for GRS-nonproxVDRE. The lowest quartile of plasma 25(OH)D compared with the highest, had a multivariate OR of 0.63 (95% CI, 0.48-0.82) for CRC. We did not observe any significant interactions between any GRSs and plasma 25(OH)D.
We did not observe evidence for the modification of genetic susceptibility for CRC according to vitamin D status, or evidence that the effect of common CRC risk alleles differed according to their proximity to putative VDR binding sites.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24670869</pmid><doi>10.1371/journal.pone.0092212</doi><tpages>e92212</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-03, Vol.9 (3), p.e92212-e92212 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1510500335 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 25-Hydroxyvitamin D Adult Aged Aged, 80 and over Alleles Binding sites Biology and Life Sciences Cancer Cancer research Cardiovascular disease Case-Control Studies Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - blood Colorectal Neoplasms - genetics Confidence intervals Deoxyribonucleic acid Disease susceptibility DNA Female Genetic aspects Genetic Loci Genetic markers Genetic Predisposition to Disease Genome-wide association studies Genomes Health aspects Health risk assessment Health risks Humans Male Medical personnel Medicine and Health Sciences Middle Aged Physicians Regulatory sequences Risk Risk Factors Single-nucleotide polymorphism Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D receptors Womens health |
| title | Joint effects of colorectal cancer susceptibility loci, circulating 25-hydroxyvitamin D and risk of colorectal cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T12%3A55%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Joint%20effects%20of%20colorectal%20cancer%20susceptibility%20loci,%20circulating%2025-hydroxyvitamin%20D%20and%20risk%20of%20colorectal%20cancer&rft.jtitle=PloS%20one&rft.au=Hiraki,%20Linda%20T&rft.date=2014-03-26&rft.volume=9&rft.issue=3&rft.spage=e92212&rft.epage=e92212&rft.pages=e92212-e92212&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0092212&rft_dat=%3Cgale_plos_%3EA478747054%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1510500335&rft_id=info:pmid/24670869&rft_galeid=A478747054&rft_doaj_id=oai_doaj_org_article_38935bc6fb0f40ffa1effb71f1b04dbb&rfr_iscdi=true |