Bovine Exome Sequence Analysis and Targeted SNP Genotyping of Recessive Fertility Defects BH1, HH2, and HH3 Reveal a Putative Causative Mutation in SMC2 for HH3

The recent discovery of bovine haplotypes with negative effects on fertility in the Brown Swiss, Holstein, and Jersey breeds has allowed producers to identify carrier animals using commercial single nucleotide polymorphism (SNP) genotyping assays. This study was devised to identify the causative mut...

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Veröffentlicht in:	PloS one 2014-03, Vol.9 (3), p.1-9
Hauptverfasser:	McClure, Matthew C, Bickhart, Derek, Null, Dan, VanRaden, Paul, Xu, Lingyang, Wiggans, George, Schroeder, Steve, Glasscock, Jarret, Armstrong, Jon, Cole, John B, Van Tassell, Curtis P, Sonstegard, Tad S
Format:	Artikel
Sprache:	eng
Schlagworte:	Abortion Agriculture Amino acid sequence Animals Biology and Life Sciences Bovidae Brown Swiss Cattle Cattle - genetics Cell division Chromosome 8 Chromosomes Chromosomes, Mammalian - genetics Dairy industry Defects Deoxyribonucleic acid DNA DNA Mutational Analysis DNA repair DNA Repair - genetics embryogenesis Exome exons Female Fertility Genetic aspects Genomes Genomics Genotyping Haplotypes Holstein Jersey Laboratories Male Mutation Nuclear Proteins - genetics Nucleotide sequence Phenylalanine Point Mutation Polymorphism Polymorphism, Single Nucleotide Proteins sequence analysis Serine Single nucleotide polymorphisms Single-nucleotide polymorphism
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