Mesenchymal stem cells from rats with chronic kidney disease exhibit premature senescence and loss of regenerative potential

Mesenchymal stem cell (MSC) transplantation has the potential for organ repair. Nevertheless, some factors might lessen the regenerative potential of MSCs, e.g. donor age or systemic disease. It is thus important to carefully assess the patient's suitability for autologous MSC transplantation....

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Veröffentlicht in:	PloS one 2014-03, Vol.9 (3), p.e92115-e92115
Hauptverfasser:	Klinkhammer, Barbara Mara, Kramann, Rafael, Mallau, Monika, Makowska, Anna, van Roeyen, Claudia Renate, Rong, Song, Buecher, Eva Bettina, Boor, Peter, Kovacova, Katarina, Zok, Stephanie, Denecke, Bernd, Stuettgen, Esther, Otten, Simon, Floege, Juergen, Kunter, Uta
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Adenine Adipogenesis Aging Animals Autografts Biology and Life Sciences Blotting, Western Bone marrow Cells, Cultured Cellular Senescence - physiology Chronic kidney failure Cloning Culture Media, Conditioned - pharmacology Cytokines - genetics Cytokines - metabolism Dehydrogenases Disease Models, Animal Exhibitions Fibroblasts - cytology Galactosidase Growth factors Health care Humans Immunoenzyme Techniques Immunoglobulins Immunology Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Kidney diseases Kidney Glomerulus - pathology Kidney transplantation Kidneys Lesions Male Medical research Medicine and Health Sciences Mesenchymal Stem Cell Transplantation Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchyme Muscle proteins Nephritis Nephritis - immunology Nephritis - pathology Nephritis - therapy Nephrology Nephropathy Proteins Purines Rats Rats, Inbred F344 Real-Time Polymerase Chain Reaction Regeneration - physiology Renal artery Renal Insufficiency, Chronic - pathology Renal Insufficiency, Chronic - therapy Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Rodents Secretion Senescence Stem cell transplantation Stem cells Studies Thy-1 Antigens - immunology Tissue Donors Transplantation Uremia β-Galactosidase
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