Overexpression of Nrf2 protects against microcystin-induced hepatotoxicity in mice

Oxidative stress and glutathione (GSH) depletion are implicated in mycocystin hepatotoxicity. To investigate the role of nuclear factor erythroid 2-related factor 2 (Nrf2) in microcystin-induced liver injury, Nrf2-null, wild-type, and Keap1-hepatocyte knockout (Keap1-HKO) mice were treated with micr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2014-03, Vol.9 (3), p.e93013
Hauptverfasser:	Lu, Yuan-Fu, Liu, Jie, Wu, Kai Connie, Qu, Qiang, Fan, Fang, Klaassen, Curtis D
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Alanine transaminase Animals Aspartate Aspartate aminotransferase Biological Transport - drug effects Biology and Life Sciences Chemical and Drug Induced Liver Injury - genetics Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - prevention & control Chemokines Chemokines - genetics Conjugation Cytokines Enzymes Gene expression Genes Glutathione Glutathione - metabolism Glutathione transferase Hepatotoxicity Inflammation Injury prevention Interleukin 6 Kinases Laboratory animals Lipid peroxidation Lipid Peroxidation - drug effects Lipids Liver Liver - cytology Liver - drug effects Liver - metabolism Liver cancer Medicine and Health Sciences Mice Microcystins - metabolism Microcystins - toxicity mRNA NF-E2-Related Factor 2 - deficiency NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Oxidative stress Oxidative Stress - drug effects Peroxidation Peroxide Polypeptides Proteins Public health Research and Analysis Methods RNA Rodents Thiobarbituric Acid Reactive Substances - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!