Open source software to control Bioflo bioreactors
Bioreactors are designed to support highly controlled environments for growth of tissues, cell cultures or microbial cultures. A variety of bioreactors are commercially available, often including sophisticated software to enhance the functionality of the bioreactor. However, experiments that the bio...
Gespeichert in:
| Veröffentlicht in: | PloS one 2014-03, Vol.9 (3), p.e92108-e92108 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e92108 |
|---|---|
| container_issue | 3 |
| container_start_page | e92108 |
| container_title | PloS one |
| container_volume | 9 |
| creator | Burdge, David A Libourel, Igor G L |
| description | Bioreactors are designed to support highly controlled environments for growth of tissues, cell cultures or microbial cultures. A variety of bioreactors are commercially available, often including sophisticated software to enhance the functionality of the bioreactor. However, experiments that the bioreactor hardware can support, but that were not envisioned during the software design cannot be performed without developing custom software. In addition, support for third party or custom designed auxiliary hardware is often sparse or absent. This work presents flexible open source freeware for the control of bioreactors of the Bioflo product family. The functionality of the software includes setpoint control, data logging, and protocol execution. Auxiliary hardware can be easily integrated and controlled through an integrated plugin interface without altering existing software. Simple experimental protocols can be entered as a CSV scripting file, and a Python-based protocol execution model is included for more demanding conditional experimental control. The software was designed to be a more flexible and free open source alternative to the commercially available solution. The source code and various auxiliary hardware plugins are publicly available for download from https://github.com/LibourelLab/BiofloSoftware. In addition to the source code, the software was compiled and packaged as a self-installing file for 32 and 64 bit windows operating systems. The compiled software will be able to control a Bioflo system, and will not require the installation of LabVIEW. |
| doi_str_mv | 10.1371/journal.pone.0092108 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1510195083</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A478752284</galeid><doaj_id>oai_doaj_org_article_90c6434de52f4913a81ad54c1404fe6b</doaj_id><sourcerecordid>A478752284</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-ed2f0c1b0a5704fbe07c2aff5597846dc3aff4fc379e8eba5e9d1e8a49eda2823</originalsourceid><addsrcrecordid>eNqNkltr2zAUx83YWLtu32BshkHZHpLpaksvg7bsEigEdnsVsnyUKChWKtm7fPspi1vi0YchgaSj3_lL51IUzzGaY1rjt5swxE77-S50MEdIEozEg-IUS0pmFUH04dH-pHiS0gYhTkVVPS5OCKuqWhBxWpDlDroyZS0DebH9Tx2h7ENpQtfH4MtLF6wPZeNCBG36ENPT4pHVPsGzcT0rvn14__Xq0-x6-XFxdXE9M5Uk_QxaYpHBDdK8Rsw2gGpDtLWcy1qwqjU0H5g1tJYgoNEcZItBaCah1UQQela8POjufEhqDDcpzDHCkiNBM7E4EG3QG7WLbqvjbxW0U38NIa6Ujr0zHpREpmKUtcCJZRJTLbBuOTOY5b9B1WStd-NrQ7OF1kAOX_uJ6PSmc2u1Cj8UlRWnUmaB16NADDcDpF5tXTLgve4gDId_13nWKKOv_kHvj26kVjoH4Dob8rtmL6ouWC1qTohgmZrfQ-XRwtblIoJ12T5xeDNx2BcafvUrPaSkFl8-_z-7_D5lz4_YNWjfr1PwQ-9Cl6YgO4AmhpQi2LskY6T2rX2bDbVvbTW2dnZ7cVygO6fbXqZ_APNA8z4</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1510195083</pqid></control><display><type>article</type><title>Open source software to control Bioflo bioreactors</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Burdge, David A ; Libourel, Igor G L</creator><contributor>Scaria, Vinod</contributor><creatorcontrib>Burdge, David A ; Libourel, Igor G L ; Scaria, Vinod</creatorcontrib><description>Bioreactors are designed to support highly controlled environments for growth of tissues, cell cultures or microbial cultures. A variety of bioreactors are commercially available, often including sophisticated software to enhance the functionality of the bioreactor. However, experiments that the bioreactor hardware can support, but that were not envisioned during the software design cannot be performed without developing custom software. In addition, support for third party or custom designed auxiliary hardware is often sparse or absent. This work presents flexible open source freeware for the control of bioreactors of the Bioflo product family. The functionality of the software includes setpoint control, data logging, and protocol execution. Auxiliary hardware can be easily integrated and controlled through an integrated plugin interface without altering existing software. Simple experimental protocols can be entered as a CSV scripting file, and a Python-based protocol execution model is included for more demanding conditional experimental control. The software was designed to be a more flexible and free open source alternative to the commercially available solution. The source code and various auxiliary hardware plugins are publicly available for download from https://github.com/LibourelLab/BiofloSoftware. In addition to the source code, the software was compiled and packaged as a self-installing file for 32 and 64 bit windows operating systems. The compiled software will be able to control a Bioflo system, and will not require the installation of LabVIEW.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0092108</identifier><identifier>PMID: 24667828</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Access control ; Automation ; Backup software ; Bioengineering ; Biology and Life Sciences ; Bioreactors ; Biotechnology ; Cell culture ; Communication ; Computer and Information Sciences ; Computer programming ; Computer programs ; Control algorithms ; Customization ; Data logging ; Downloading ; Engineering and Technology ; Fermentation ; Freeware ; Hardware ; Logging ; Microorganisms ; Open source software ; Operating systems ; Personal computers ; Programming Languages ; Protocol (computers) ; Researchers ; Sensors ; Software ; Software Design ; Source code ; Stability ; Tissues</subject><ispartof>PloS one, 2014-03, Vol.9 (3), p.e92108-e92108</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Libourel, Burdge. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Libourel, Burdge 2014 Libourel, Burdge</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-ed2f0c1b0a5704fbe07c2aff5597846dc3aff4fc379e8eba5e9d1e8a49eda2823</citedby><cites>FETCH-LOGICAL-c692t-ed2f0c1b0a5704fbe07c2aff5597846dc3aff4fc379e8eba5e9d1e8a49eda2823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965399/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965399/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24667828$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Scaria, Vinod</contributor><creatorcontrib>Burdge, David A</creatorcontrib><creatorcontrib>Libourel, Igor G L</creatorcontrib><title>Open source software to control Bioflo bioreactors</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Bioreactors are designed to support highly controlled environments for growth of tissues, cell cultures or microbial cultures. A variety of bioreactors are commercially available, often including sophisticated software to enhance the functionality of the bioreactor. However, experiments that the bioreactor hardware can support, but that were not envisioned during the software design cannot be performed without developing custom software. In addition, support for third party or custom designed auxiliary hardware is often sparse or absent. This work presents flexible open source freeware for the control of bioreactors of the Bioflo product family. The functionality of the software includes setpoint control, data logging, and protocol execution. Auxiliary hardware can be easily integrated and controlled through an integrated plugin interface without altering existing software. Simple experimental protocols can be entered as a CSV scripting file, and a Python-based protocol execution model is included for more demanding conditional experimental control. The software was designed to be a more flexible and free open source alternative to the commercially available solution. The source code and various auxiliary hardware plugins are publicly available for download from https://github.com/LibourelLab/BiofloSoftware. In addition to the source code, the software was compiled and packaged as a self-installing file for 32 and 64 bit windows operating systems. The compiled software will be able to control a Bioflo system, and will not require the installation of LabVIEW.</description><subject>Access control</subject><subject>Automation</subject><subject>Backup software</subject><subject>Bioengineering</subject><subject>Biology and Life Sciences</subject><subject>Bioreactors</subject><subject>Biotechnology</subject><subject>Cell culture</subject><subject>Communication</subject><subject>Computer and Information Sciences</subject><subject>Computer programming</subject><subject>Computer programs</subject><subject>Control algorithms</subject><subject>Customization</subject><subject>Data logging</subject><subject>Downloading</subject><subject>Engineering and Technology</subject><subject>Fermentation</subject><subject>Freeware</subject><subject>Hardware</subject><subject>Logging</subject><subject>Microorganisms</subject><subject>Open source software</subject><subject>Operating systems</subject><subject>Personal computers</subject><subject>Programming Languages</subject><subject>Protocol (computers)</subject><subject>Researchers</subject><subject>Sensors</subject><subject>Software</subject><subject>Software Design</subject><subject>Source code</subject><subject>Stability</subject><subject>Tissues</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkltr2zAUx83YWLtu32BshkHZHpLpaksvg7bsEigEdnsVsnyUKChWKtm7fPspi1vi0YchgaSj3_lL51IUzzGaY1rjt5swxE77-S50MEdIEozEg-IUS0pmFUH04dH-pHiS0gYhTkVVPS5OCKuqWhBxWpDlDroyZS0DebH9Tx2h7ENpQtfH4MtLF6wPZeNCBG36ENPT4pHVPsGzcT0rvn14__Xq0-x6-XFxdXE9M5Uk_QxaYpHBDdK8Rsw2gGpDtLWcy1qwqjU0H5g1tJYgoNEcZItBaCah1UQQela8POjufEhqDDcpzDHCkiNBM7E4EG3QG7WLbqvjbxW0U38NIa6Ujr0zHpREpmKUtcCJZRJTLbBuOTOY5b9B1WStd-NrQ7OF1kAOX_uJ6PSmc2u1Cj8UlRWnUmaB16NADDcDpF5tXTLgve4gDId_13nWKKOv_kHvj26kVjoH4Dob8rtmL6ouWC1qTohgmZrfQ-XRwtblIoJ12T5xeDNx2BcafvUrPaSkFl8-_z-7_D5lz4_YNWjfr1PwQ-9Cl6YgO4AmhpQi2LskY6T2rX2bDbVvbTW2dnZ7cVygO6fbXqZ_APNA8z4</recordid><startdate>20140325</startdate><enddate>20140325</enddate><creator>Burdge, David A</creator><creator>Libourel, Igor G L</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140325</creationdate><title>Open source software to control Bioflo bioreactors</title><author>Burdge, David A ; Libourel, Igor G L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-ed2f0c1b0a5704fbe07c2aff5597846dc3aff4fc379e8eba5e9d1e8a49eda2823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Access control</topic><topic>Automation</topic><topic>Backup software</topic><topic>Bioengineering</topic><topic>Biology and Life Sciences</topic><topic>Bioreactors</topic><topic>Biotechnology</topic><topic>Cell culture</topic><topic>Communication</topic><topic>Computer and Information Sciences</topic><topic>Computer programming</topic><topic>Computer programs</topic><topic>Control algorithms</topic><topic>Customization</topic><topic>Data logging</topic><topic>Downloading</topic><topic>Engineering and Technology</topic><topic>Fermentation</topic><topic>Freeware</topic><topic>Hardware</topic><topic>Logging</topic><topic>Microorganisms</topic><topic>Open source software</topic><topic>Operating systems</topic><topic>Personal computers</topic><topic>Programming Languages</topic><topic>Protocol (computers)</topic><topic>Researchers</topic><topic>Sensors</topic><topic>Software</topic><topic>Software Design</topic><topic>Source code</topic><topic>Stability</topic><topic>Tissues</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Burdge, David A</creatorcontrib><creatorcontrib>Libourel, Igor G L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Burdge, David A</au><au>Libourel, Igor G L</au><au>Scaria, Vinod</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Open source software to control Bioflo bioreactors</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-03-25</date><risdate>2014</risdate><volume>9</volume><issue>3</issue><spage>e92108</spage><epage>e92108</epage><pages>e92108-e92108</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Bioreactors are designed to support highly controlled environments for growth of tissues, cell cultures or microbial cultures. A variety of bioreactors are commercially available, often including sophisticated software to enhance the functionality of the bioreactor. However, experiments that the bioreactor hardware can support, but that were not envisioned during the software design cannot be performed without developing custom software. In addition, support for third party or custom designed auxiliary hardware is often sparse or absent. This work presents flexible open source freeware for the control of bioreactors of the Bioflo product family. The functionality of the software includes setpoint control, data logging, and protocol execution. Auxiliary hardware can be easily integrated and controlled through an integrated plugin interface without altering existing software. Simple experimental protocols can be entered as a CSV scripting file, and a Python-based protocol execution model is included for more demanding conditional experimental control. The software was designed to be a more flexible and free open source alternative to the commercially available solution. The source code and various auxiliary hardware plugins are publicly available for download from https://github.com/LibourelLab/BiofloSoftware. In addition to the source code, the software was compiled and packaged as a self-installing file for 32 and 64 bit windows operating systems. The compiled software will be able to control a Bioflo system, and will not require the installation of LabVIEW.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24667828</pmid><doi>10.1371/journal.pone.0092108</doi><tpages>e92108</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-03, Vol.9 (3), p.e92108-e92108 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1510195083 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Access control Automation Backup software Bioengineering Biology and Life Sciences Bioreactors Biotechnology Cell culture Communication Computer and Information Sciences Computer programming Computer programs Control algorithms Customization Data logging Downloading Engineering and Technology Fermentation Freeware Hardware Logging Microorganisms Open source software Operating systems Personal computers Programming Languages Protocol (computers) Researchers Sensors Software Software Design Source code Stability Tissues |
| title | Open source software to control Bioflo bioreactors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T08%3A47%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Open%20source%20software%20to%20control%20Bioflo%20bioreactors&rft.jtitle=PloS%20one&rft.au=Burdge,%20David%20A&rft.date=2014-03-25&rft.volume=9&rft.issue=3&rft.spage=e92108&rft.epage=e92108&rft.pages=e92108-e92108&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0092108&rft_dat=%3Cgale_plos_%3EA478752284%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1510195083&rft_id=info:pmid/24667828&rft_galeid=A478752284&rft_doaj_id=oai_doaj_org_article_90c6434de52f4913a81ad54c1404fe6b&rfr_iscdi=true |