Sulforaphane induces oxidative stress and death by p53-independent mechanism: implication of impaired glutathione recycling

Sulforaphane (SFN) is a naturally-occurring isothiocyanate best known for its role as an indirect antioxidant. Notwithstanding, in different cancer cell lines, SFN may promote the accumulation of reactive oxygen species (ROS) and cause cell death e.g. by apoptosis. Osteosarcoma often becomes chemore...

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Veröffentlicht in:	PloS one 2014-03, Vol.9 (3), p.e92980
Hauptverfasser:	Ferreira de Oliveira, José Miguel P, Costa, Maria, Pedrosa, Tiago, Pinto, Pedro, Remédios, Catarina, Oliveira, Helena, Pimentel, Francisco, Almeida, Luís, Santos, Conceição
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Analysis Antioxidants Antioxidants (Nutrients) Antioxidants - pharmacology Apoptosis Apoptosis - drug effects Biocompatibility Biology Biology and Life Sciences Biomarkers Biomarkers, Tumor - metabolism Biomedical materials Biotechnology Bone cancer Brassicaceae Cancer Cancer therapies Caspase Caspase-3 Cell culture Cell cycle Cell death Cell Line, Tumor Cell Survival - drug effects Chemotherapy Cytotoxicity Detoxification Drug resistance Drugs Enzymatic activity Enzyme activity Enzyme Inhibitors - pharmacology Enzymes Gene expression Glutathione Glutathione - metabolism Glutathione peroxidase Glutathione reductase Humans Inhibition Intracellular Space - drug effects Intracellular Space - enzymology Intracellular Space - metabolism Isothiocyanate Isothiocyanates - pharmacology Kinases Laboratories Leukemia Medical prognosis Medicine and Health Sciences Morphology Osteosarcoma Osteosarcoma - pathology Oxidative stress Oxidative Stress - drug effects Oxygen p53 Protein Peroxidase Reactive oxygen species Sarcoma Sulforaphane Sulfoxides Thiols Time Factors Tumor cell lines Tumor proteins
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