Novel insight into mutational landscape of head and neck squamous cell carcinoma

Development of head and neck squamous cell carcinoma (HNSCC) is characterized by accumulation of mutations in several oncogenes and tumor suppressor genes. We have formerly described the mutation pattern of HNSCC and described NOTCH signaling pathway alterations. Given the complexity of the HNSCC, h...

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Veröffentlicht in:	PloS one 2014-03, Vol.9 (3), p.e93102
Hauptverfasser:	Gaykalova, Daria A, Mambo, Elizabeth, Choudhary, Ashish, Houghton, Jeffery, Buddavarapu, Kalyan, Sanford, Tiffany, Darden, Will, Adai, Alex, Hadd, Andrew, Latham, Gary, Danilova, Ludmila V, Bishop, Justin, Li, Ryan J, Westra, William H, Hennessey, Patrick, Koch, Wayne M, Ochs, Michael F, Califano, Joseph A, Sun, Wenyue
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alterations Analysis Biology and Life Sciences Cancer Cancer genetics Cancer therapies Carcinogenesis Carcinogens Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Deoxyribonucleic acid DNA DNA Mutational Analysis Epigenetics Fibroblast growth factor receptors Gene amplification Gene frequency Gene sequencing Genes Genetic aspects Genetics Head & neck cancer Head and neck cancer Head and Neck Neoplasms - genetics Head and Neck Neoplasms - pathology Health aspects Human papillomavirus Humans Informatics Kinases Leukemia Medicine and Health Sciences Middle Aged Mortality Mutation Notch protein Notch1 protein Otolaryngology p53 Protein Papillomavirus infections Pathology Patients Science Signal transduction Signaling Smoking Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck Surgery Tissues Tumor proteins Tumor suppressor genes Tumorigenesis
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